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Antioch on the Orontes () was a Hellenistic Greek city founded by Seleucus I Nicator in 300 BC. It was one of the greatest and most important Greek cities of the Hellenistic period. The city served as the capital of the Greek Seleucid Empire and later as regional capital to both the Roman and Byzantine Empire. During the Crusades, Antioch served as the capital of the Principality of Antioch, one o... Wikipedia