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1. • • Rickettsial infections vary in severity based on the virulence of the Rickettsia species and host factors, such as the degree of immunocompetence. R rickettsii and R prowazekii are considered the most virulent species and are associated with significant mortality if the infected individual is not diagnosed and treated early.
     www.ncbi.nlm.nih.gov › books › NBK431127

     Rickettsial Infection - StatPearls - NCBI Bookshelf

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   Is Rickettsia prowazekii the same as spotted fever?

   • The causative organisms ( Rickettsia prowazekii and Rickettsia typhi) are similar to those of the spotted fever group but are antigenically distinct. The rickettsial agents of scrub typhus have a single taxonomic name: Orientia tsutsugamushi.

   Rickettsial Infection: Background, Pathophysiology, Etiology

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   Are R rickettsii and R prowazekii virulent?

   • R rickettsii and R prowazekii are considered the most virulent species and are associated with significant mortality if the infected individual is not diagnosed and treated early. For example, patients with Rocky Mountain spotted fever have mortality rates are as high as 30% without prompt diagnosis and antibiotic treatment.

   Rickettsial Infection - StatPearls - NCBI Bookshelf

   www.ncbi.nlm.nih.gov/books/NBK431127/

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   What are rickettsial diseases?

   • Rickettsial illnesses, comprising mainly spotted fever group, typhus group and scrub typhus, are vector-borne re-emerging or newly emerging febrile illnesses where humans are an accidental dead-end host. They are a major cause of non-malarial febrile illnesses among returned travellers.

   Rickettsial illnesses, a leading cause of acute febrile illness

   www.rcpjournals.org/content/clinmedicine/22/1/2

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   What phylogeny does Rickettsia have?

   • Contemporary phylogeny of Rickettsia recognizes three pathogenic clades, the classic spotted fever and typhus groups and a transitional group in addition to numerous other clades of organisms of undetermined pathogenicity that are ancestral ( 2) to the pathogens.

   Pathogenesis of Rickettsial Diseases: Pathogenic and Immune Mechanis…

   www.ncbi.nlm.nih.gov/pmc/articles/PMC6505701/

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3. www.ncbi.nlm.nih.gov › pmc › articlesPathogenicity and virulence of Rickettsia - PMC

   www.ncbi.nlm.nih.gov › pmc › articles

   Oct 8, 2022 · Recent investigations demonstrated that pathogenic Rickettsia species, such as R. rickettsii and R. conorii, have evolved to resist bactericidal mechanisms and establish a replicative niche within the cytosolic compartments of professional phagocytes, such as macrophages, suggesting that rickettsial survival in immune cells may contribute to ...

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     1. Rickettsia attaches to host cells via interaction of...

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     Gene Protein Putative functions Predicted secretion...

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     A. Rickettsial entry into mammalian cells is mediated by...

4. www.ncbi.nlm.nih.gov › pmc › articlesPathogenesis of Rickettsial Diseases: Pathogenic and Immune ...

   www.ncbi.nlm.nih.gov › pmc › articles

   Jan 1, 2019 · Sca4 is complete in the virulent strain of R. prowazekii Rp22 . Sca4 is expressed R. bellii, but appears to be absent in R. canadensis . Sca4 is active in L929 cells infected with R. typhi in vitro and in cat fleas in vivo .

   • Author: Abha Sahni, Rong Fang, Sanjeev K. Sahni, David H. Walker
   • DOI: 10.1146/annurev-pathmechdis-012418-012800

   • Publish Year: 2019
   • Published: 2019/01/01

5. www.ncbi.nlm.nih.gov › books › NBK431127Rickettsial Infection - StatPearls - NCBI Bookshelf

   www.ncbi.nlm.nih.gov › books › NBK431127

   Jul 17, 2023 · Rickettsial infections are caused by a variety of obligate intracellular bacteria in the genus Rickettsia and are grouped into one of four categories: spotted fever group, typhus group, ancestral group, and transitional group. [3] .

   • Author: Jessica Snowden, Megan Ladd, Kevin C. King

   • Published: 2023/07/17

6. reference.medscape.com › article › 968385Rickettsial Infection: Background, Pathophysiology, Etiology

   reference.medscape.com › article › 968385

   Typhus group. These are similar diseases that differ epidemiologically. The causative organisms ( Rickettsia prowazekii and Rickettsia typhi) are similar to those of the spotted fever group but...

7. en.wikipedia.org › wiki › Rickettsia_rickettsiiRickettsia rickettsii - Wikipedia

   en.wikipedia.org › wiki › Rickettsia_rickettsii

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   R. rickettsii's survival in immune system cells increases the pathogen's virulence in mammalian hosts. Actin-Based Motility (ABM) is a virulence factor that allows for the pathogen to evade the host's immune cells and spread to neighboring cells.

   • Species: R. rickettsii
   • Family: Rickettsiaceae

   • Class: Alphaproteobacteria
   • Genus: Rickettsia

8. www.rcpjournals.org › content › clinmedicineRickettsial illnesses, a leading cause of acute febrile ...

   www.rcpjournals.org › content › clinmedicine

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   ABSTRACT. Rickettsial illnesses, comprising mainly spotted fever group, typhus group and scrub typhus, are vector-borne re-emerging or newly emerging febrile illnesses where humans are an accidental dead-end host. They are a major cause of non-malarial febrile illnesses among returned travellers.

9. www.cdc.gov › typhus › epidemicEpidemic Typhus | Typhus Fevers | CDC

   www.cdc.gov › typhus › epidemic

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   Nov 13, 2020 · Epidemic typhus, also called louse-borne typhus, is an uncommon disease caused by a bacteria called Rickettsia prowazekii. Epidemic typhus is spread to people through contact with infected body lice. Though epidemic typhus was responsible for millions of deaths in previous centuries, it is now considered a rare disease.