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  2. While studying E. coli bacteria, enzymologist Arthur Kornberg discovered that DNA polymerases catalyze DNA synthesis. Kornberg's experiment involved mixing all of the basic...

  3. In the first Classic, Kornberg and his colleagues describe the purification of DNA polymerase from E. coli. In the second Classic, they report that polymerized DNA, Mg2 , and all four deoxynucleoside triphosphates (adenine, guanine, cytosine, and thymine) are needed for DNA synthesis to occur.

  4. Arthur Kornberg's Discovery of DNA Polymerase I. Enzymatic Synthesis of Deoxyribonucleic Acid. I. Preparation of Substrates and Partial Purification of an Enzyme from Escherichia coli (Lehman, I. R., Bessman, M. J., Simms, E. S., and Kornberg, A. (1958) J. Biol. Chem. 233, 163-170) Photo courtesy of the National Library of Medicine.

  5. PDF | On Dec 9, 2005, Nicole Kresge and others published Arthur Kornberg's Discovery of DNA Polymerase I | Find, read and cite all the research you need on ResearchGate

  6. DNA polymerase, an enzyme discovered in 1955, has the remarkable capacity to catalyze the template-directed synthesis of DNA (1, 2). The discovery of DNA polymerase has contributed in major ways to our present day understanding of how DNA is replicated and repaired and how it is transcribed.

  7. problem of synthesizing DNA. While at Washington University from 1953 to 1959, he discovered the first DNA polymerase and established DNA synthesis as a template-driven process, for which he shared the 1959 Nobel Prize in Physiology or Medicine. Together with talented students and post-doctoral fellows, Arthur accomplished what

  8. › articles › nrm1787PERSPECTIVES - Nature

    TIMELINE. The eureka enzyme: the discovery of DNA polymerase. Errol C. Friedberg. Abstract | The identification and partial purification by Arthur Kornberg and his colleagues in 1956 of an...

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