Yahoo Web Search

Search results

1. en.wikipedia.org › wiki › Attenuated_vaccineAttenuated vaccine - Wikipedia

   en.wikipedia.org › wiki › Attenuated_vaccine

   • Cached

   Attenuated vaccine. An attenuated vaccine (or a live attenuated vaccine, LAV) is a vaccine created by reducing the virulence of a pathogen, but still keeping it viable (or "live"). [1] Attenuation takes an infectious agent and alters it so that it becomes harmless or less virulent. [2]

2. www.ncbi.nlm.nih.gov › pmc › articlesCould live attenuated vaccines better control COVID-19? - PMC

   www.ncbi.nlm.nih.gov › pmc › articles

   Sep 9, 2021 · Known live attenuated vaccines include those against the measles virus, rubella virus, varicella zoster virus, and influenza virus. The strains used for these vaccines were attenuated mainly through adaptation to cold culture conditions, or through non-human animals [46] , [47] , resulting in viruses with slower proliferation rates in the human ...

   • Author: Shinya Okamura, Hirotaka Ebina
   • DOI: 10.1016/j.vaccine.2021.08.018

   • Publish Year: 2021
   • Publication: Vaccine. 2021 Sep 15; 39(39): 5719-5726.

3. www.cdc.gov › flu › preventDifferent Types of Flu Vaccines | CDC

   www.cdc.gov › flu › prevent

   • Cached

   Mar 14, 2024 · Nasal Spray Flu Vaccine. Live Attenuated Influenza Vaccine [LAIV] (FluMist Quadrivalent) is given as a nasal spray. This vaccine is made with attenuated (weakened) live flu viruses, and is approved for use in people aged 2 through 49 years. This vaccine is not recommended for use in pregnant people, immunocompromised people, or people with ...

4. en.wikipedia.org › wiki › Live_attenuated_influenzaLive attenuated influenza vaccine - Wikipedia

   en.wikipedia.org › wiki › Live_attenuated_influenza

   • Cached

   Live attenuated influenza vaccine (LAIV) is a type of influenza vaccine in the form of a nasal spray that is recommended for the prevention of influenza. It was developed by the Syrian-American epidemiologist Hunein Maassab. It is an attenuated live vaccine, unlike other influenza vaccines, which are inactivated vaccines.

   • Trade names: Flumist Quadrivalent, Fluenz Tetra
   • Target: Influenza

   • Routes of administration: Intranasal
   • Vaccine type: Attenuated

5. People also ask

   How does virus attenuation work?

   • Attenuation is typically achieved by evolving the virus (for example by growth in a new environment) or genetically modifying it so as to reduce its growth rate following infection of the host [ 5 – 10 ]. Here we suggest an alternative approach to attenuation, one that directs the virus toward reduced viral defenses against host immunity.

   Directed attenuation to enhance vaccine immunity - PMC

   www.ncbi.nlm.nih.gov/pmc/articles/PMC7877766/

   See all results for this question

   How is adenoviral attenuation achieved in LAV design?

   • Improved targeting of adenoviral vectors has also been achieved by the addition of miRNA binding sites to the 3’ untranslated region of the E1A transcript 54, 55. In LAV design, empiric attenuation of viruses is often accomplished by changing the tissue tropism of a virus through repeated passage in a new cell type.

   Rationalizing the development of live attenuated virus vaccines

   www.ncbi.nlm.nih.gov/pmc/articles/PMC2883798/

   See all results for this question

   How can we maintain live attenuation?

   • Using these methods, it is possible to construct strains with various mutations, and thus maintain live attenuation, even when one responsible mutation is replaced by the wild type sequence. In addition, adverse reactions due to the proliferation of the live attenuated vaccine strains in the nasal cavity should be evaluated.

   Could live attenuated vaccines better control COVID-19? - PMC

   www.ncbi.nlm.nih.gov/pmc/articles/PMC8354792/

   See all results for this question

   What is the first step in directing attenuation?

   • The first step in directing attenuation involves characterizing the different viral proteins and how they interact with the cells and molecules involved in the generation of immune responses—the subject of recent advances in molecular and cellular virology and immunology (reviewed in [ 24, 25 ]).

   Directed attenuation to enhance vaccine immunity - PMC

   www.ncbi.nlm.nih.gov/pmc/articles/PMC7877766/

   See all results for this question

6. www.ncbi.nlm.nih.gov › pmc › articlesDirected attenuation to enhance vaccine immunity - PMC

   www.ncbi.nlm.nih.gov › pmc › articles

   Feb 1, 2021 · Attenuation is typically achieved by evolving the virus (for example by growth in a new environment) or genetically modifying it so as to reduce its growth rate following infection of the host [5–10]. Here we suggest an alternative approach to attenuation, one that directs the virus toward reduced viral defenses against host immunity.

   • Author: Rustom Antia, Hasan Ahmed, James J. Bull
   • DOI: 10.1371/journal.pcbi.1008602

   • Publish Year: 2021
   • Publication: PLoS Comput Biol. 2021 Feb; 17(2): e1008602.

7. en.wikipedia.org › wiki › VaccineVaccine - Wikipedia

   en.wikipedia.org › wiki › Vaccine

   • Cached

   A vaccine is a biological preparation that provides active acquired immunity to a particular infectious or malignant disease. [1] [2] The safety and effectiveness of vaccines has been widely studied and verified. [3] [4] A vaccine typically contains an agent that resembles a disease-causing microorganism and is often made from weakened or ...

8. www.ncbi.nlm.nih.gov › pmc › articlesAn Overview of Influenza Viruses and Vaccines - PMC

   www.ncbi.nlm.nih.gov › pmc › articles

   Sep 17, 2021 · 2. Influenza Virus Life Cycle. The replication cycle of the influenza virus goes through several stages as shown in Figure 2, and is as follows: (1) virus attachment to the sialic acid receptor, (2) entry of the virus into the host cell, (3) fusion and uncoating of the virus particles, (4) vRNPs entry into the nucleus followed by transcription and replication of the viral RNA genome then ...