- Azithromycin is an azalide, a type of macrolide antibiotic. It works by decreasing the production of protein, thereby stopping bacterial growth. Azithromycin was discovered in 1980 by Pliva and approved for medical use in 1988. It is on the World Health Organization's List of Essential Medicines.
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Azithromycin is an antibiotic used for the treatment of a number of bacterial infections. This includes middle ear infections, strep throat, pneumonia, traveler's diarrhea, and certain other intestinal infections. It can also be used for a number of sexually transmitted infections, including chlamydia and gonorrhea infections. Along with other medications, it may also be used for malaria. It can be taken by mouth or intravenously with doses once per day. Common side effects include nausea, vomit
- Zithromax, Azithrocin, others
- AU: B1, US: B (No risk in non-human studies)
Erythromycin is an antibiotic used for the treatment of a number of bacterial infections. This includes respiratory tract infections, skin infections, chlamydia infections, pelvic inflammatory disease, and syphilis.
- AU: A, US: B (No risk in non-human studies)
- liver (under 5% excreted unchanged)
- Eryc, Erythrocin, others
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Common Trade Names: Zithromax, Z-Pak, Zmax; Adult Dosing. Babesiosis (In combination with Atovaquone) [Mild/Moderate 500mg PO x1 on day 1, then 250mg PO q24h x7-10 days. Severe 500mg IV q24hr for 7 to 10 days] Bacterial Infections [500mg PO x1 on day 1, then 250mg PO q24h x4 days]
Ideal sources for Wikipedia's health content are defined in the guideline Wikipedia:Identifying reliable sources (medicine) and are typically review articles. Here are links to possibly useful sources of information about Azithromycin. PubMed provides review articles from the past five years (limit to free review articles)
- Indications and Usage For Azithromycin Tablets
- Azithromycin Tablets Dosage and Administration
- Dosage Forms and Strengths
- Warnings and Precautions
- Adverse Reactions
- Drug Interactions
- Use in Specific Populations
- Azithromycin Tablets Description
- Nonclinical Toxicology
- Clinical Studies
- How Supplied/Storage and Handling
- Patient Counseling Information
- Patient Information
- Package Labeling
Azithromycin Tablets are a macrolide antibacterial drug indicated for the treatment of patients with mild to moderate infections caused by susceptible strains of the designated microorganisms in the specific conditions listed below. Recommended dosages and durations of therapy in adult and pediatric patient populations vary in these indications [see Dosage and Administration ( 2)].
[see Indications and Usage ( 1.1) and Clinical Pharmacology ( 12.3)]Azithromycin Tablets can be taken with or without food.
Azithromycin Tablets USP, 250 mg are supplied as white, oval, biconvex, unscored, film-coated tablets, debossed with “787” on one side and “PLIVA” on the other, containing azithromycin monohydrate equivalent to 250 mg of azithromycin, USP, available in boxes of 1 card x 6 tablets, in a bundle of 3 boxes x 6 tablets (18), and in bottles of 30 tablets.Azithromycin Tablets USP, 500 mg are supplied as blue, capsule shaped, biconvex, unscored, film-coated tablets, debossed with “788” on one side a...
Azithromycin Tablets are contraindicated in patients with known hypersensitivity to azithromycin, erythromycin, any macrolide or ketolide drug.
Serious allergic reactions, including angioedema, anaphylaxis, and dermatologic reactions including Acute Generalized Exanthematous Pustulosis (AGEP), Stevens-Johnson syndrome, and toxic epidermal necrolysis have been reported in patients on azithromycin therapy [see Contraindications ( 4.1)] .Fatalities have been reported. Cases of Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) have also been reported. Despite initially successful symptomatic treatment of the allergic symptoms...
Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice.In clinical trials, most of the reported side effects were mild to moderate in severity and were reversible upon discontinuation of the drug. Potentially serious adverse reactions of angioedema and cholestatic jaundice were reported....
Coadministration of nelfinavir at steady-state with a single oral dose of azithromycin resulted in increased azithromycin serum concentrations. Although a dose adjustment of azithromycin is not recommended when administered in combination with nelfinavir, close monitoring for known adverse reactions of azithromycin, such as liver enzyme abnormalities and hearing impairment, is warranted [see Adverse Reactions ( 6)].
Teratogenic EffectsPregnancy Category BReproduction studies have been performed in rats and mice at doses up to moderately maternally toxic dose concentrations (i.e., 200 mg/kg/day). These daily doses in rats and mice, based on body surface area, are estimated to be 4 and 2 times, respectively, an adult daily dose of 500 mg. In the animal studies, no evidence of harm to the fetus due to azithromycin was found. There are, however, no adequate and well-controlled studies in pregnant women. Beca...
Adverse reactions experienced at higher than recommended doses were similar to those seen at normal doses particularly nausea, diarrhea, and vomiting. In the event of overdosage, general symptomatic and supportive measures are indicated as required.
Azithromycin Tablets USP contain the active ingredient azithromycin, USP, a macrolide antibacterial drug, for oral administration. Azithromycin, USP has the chemical name (2 R,3 S,4 R,5 R,8 R,10 R,11 R,12 S,13 S,14 R)-13-[(2,6-dideoxy-3- C-methyl-3- O-methyl-α-L- ribo-hexopyranosyl) oxy]-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D- xylo-hexopyranosyl]oxy]-1-oxa-6-azacyclopentadecan-15-one. Azithromycin, USP is derived from erythromycin; how...
Long-term studies in animals have not been performed to evaluate carcinogenic potential. Azithromycin has shown no mutagenic potential in standard laboratory tests: mouse lymphoma assay, human lymphocyte clastogenic assay, and mouse bone marrow clastogenic assay. No evidence of impaired fertility due to azithromycin was found in rats given daily doses up to 10 mg/kg (approximately 0.2 times an adult daily dose of 500 mg based on body surface area).
Acute Bacterial Exacerbations of Chronic BronchitisIn a randomized, double-blind controlled clinical trial of acute exacerbation of chronic bronchitis (AECB), azithromycin (500 mg once daily for 3 days) was compared with clarithromycin (500 mg twice daily for 10 days). The primary endpoint of this trial was the clinical cure rate at Days 21 to 24. For the 304 patients analyzed in the modified intent-to-treat analysis at the Days 21 to 24 visit, the clinical cure rate for 3 days of azithromyci...
Azithromycin Tablets USP, 500 mg are supplied as blue, capsule shaped, biconvex, unscored, film-coated tablets, debossed with “788” on one side and “PLIVA” on the other, containing azithromycin monohydrate equivalent to 500 mg of azithromycin, USP, available in boxes of 1 card x 1 tablets (NDC 54348-857-00), in a bundle of 3 boxes x 2 tablets (9) (NDC 54348-857-01), and in bottles of 6 tablets (NDC 54348-857-02).Store at 20º to 25°C (68° to 77°F) [See USP Controlled Room Temperature].KEEP THI...
General Patient CounselingAzithromycin Tablets and oral suspension can be taken with or without food.Patients should also be cautioned not to take aluminum- and magnesium-containing antacids and azithromycin simultaneously.The patient should be directed to discontinue azithromycin immediately and contact a physician if any signs of an allergic reaction occur.Direct parents or caregivers to contact their physician if vomiting and irritability with feeding occurs in the infant.Patients should b...
Azithromycin (a ZITH roe MYE sin)TabletsRead this Patient Information leaflet before you start taking Azithromycin Tablets and each time you get a refill. There may be new information. This information does not take the place of talking to your healthcare provider about your medical condition or your treatment.What are Azithromycin Tablets?Azithromycin Tablets are a macrolide antibiotic prescription medicine used in adults 18 years or older to treat certain infections caused by certain germs...
1. Can you drink alcohol with Z-Pak? 2. Zithromax Z-Pak - can Tums (antacids) be taken with Z-Pak? 3. Azithromycin - Can I drink a glass of wine at night if I have taken the medicine in the day? 4. Azithromycin - can you cut the pill in half? 5. Taking azithromycin for chlamydia, how long to clear infection? 6. Is azithromycin OK for men with chlamydia? 7. What is the recommended treatment and dose for chlamydia? 8. Was azithromycin in my system long enough to treat chlamydia after throwing...
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Grits are prepared by adding four parts boiling water or milk (seasoned with 1 ⁄ 4 tsp of salt for each cup of liquid) to one part cornmeal. Cover and cook for 20 to 45 minutes over medium-low, stirring regularly.