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  1. Feb 19, 2022 · A recent study evaluated the efficacy of four treatments (5% imiquimod cream, methyl aminolevulinate PDT [MAL-PDT], 5% 5-FU cream, and 0.015% ingenol mebutate gel [IGM]) for AK located on the head and neck. Results showed that 5% 5-FU cream was the most effective among the field-directed treatments.

  2. Strong recommendations are made for using ultraviolet protection, topical imiquimod, topical 5-fluorouracil, and cryosurgery. Conditional recommendations are made for the use of photodynamic therapy and diclofenac for the treatment of AK, both individually and as part of combination therapy regimens. Key words. actinic keratosis guidelines.

    • Daniel B. Eisen, Maryam M. Asgari, Daniel D. Bennett, Suzanne M. Connolly, Robert P. Dellavalle, Est...
    • 2021
  3. Conclusions: Strong recommendations are made for using ultraviolet protection, topical imiquimod, topical 5-fluorouracil, and cryosurgery. Conditional recommendations are made for the use of photody-namic therapy and diclofenac for the treatment of AK, both individually and as part of combination therapy regimens.

  4. Mar 13, 2019 · At 12 months after the end of treatment, 5% fluorouracil cream was the most effective treatment. The following NEJM Journal Watch summary explains the study: Treating Actinic Keratosis:...

  5. The reason for treating actinic keratosis is to stop the lesion from progressing to squamous cell carcinoma (SCC). The best treatment option for actinic keratosis will depend on how many lesions you have and where they are located. At times, certain treatments may be used together.

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  7. Treatment options for AK include field-directed therapies, such as topical medications and photodynamic therapy, and lesion-directed therapies, like cryosurgery and laser ablation. Analysis of the evidence from a systematic review based on five research questions resulted in eighteen evidence-based recommendations and suggests there are several ...

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