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  2. Jul 7, 2022 · Cryotherapy is the most commonly used lesion-targeted, destructive treatment, in which liquid nitrogen is applied to the lesion using a spray or cotton swab [ 2 ]. Cryotherapy is easy to implement and has the advantage of not having to rely on the patient’s compliance in the treatment process.

    • 10.3390/jcm11143953
    • 2022/07
    • J Clin Med. 2022 Jul; 11(14): 3953.
  3. Feb 19, 2022 · A recent study evaluated the efficacy of four treatments (5% imiquimod cream, methyl aminolevulinate PDT [MAL-PDT], 5% 5-FU cream, and 0.015% ingenol mebutate gel [IGM]) for AK located on the head and neck. Results showed that 5% 5-FU cream was the most effective among the field-directed treatments.

    • 10.1007/s40257-022-00674-3
    • 2022
    • Am J Clin Dermatol. 2022; 23(3): 339-352.
  4. Mar 6, 2019 · Current guidelines provide no clear recommendations about which treatment approach is preferred. 14-17 Frequently prescribed and studied field-directed treatment approaches are fluorouracil...

    • Maud H E Jansen, Janneke P H M Kessels, Patty J Nelemans, Nina Kouloubis, Aimee H M M Arits, Han P A...
    • 2019
  5. Jun 7, 2021 · Treatment options for AK include field-directed therapies, such as topical medications and photodynamic therapy, and lesion-directed therapies, such as cryosurgery and laser ablation. This executive summary of the Guidelines of Care for the Management of Actinic Keratosis

    • Daniel B. Eisen, Maryam M. Asgari, Daniel D. Bennett, Suzanne M. Connolly, Robert P. Dellavalle, Est...
    • 2021
  6. Mar 24, 2021 · Derm Topics. Actinic Keratoses: Evidence-Based Treatment Options. March 24, 2021 Jacqueline McKesey, MD, MS. Dr. Hanke, a dermatologic surgeon who needs no introduction (but I’ll give one anyway!) provided us with an evidence-based discussion of field treatments available for actinic keratoses at ODAC 2021 conference.

  7. Mar 13, 2019 · At 12 months after the end of treatment, 5% fluorouracil cream was the most effective treatment. The following NEJM Journal Watch summary explains the study: Treating Actinic Keratosis:...

  8. Strong recommendations are made for using ultraviolet protection, topical imiquimod, topical 5-fluorouracil, and cryosurgery. Conditional recommendations are made for the use of photodynamic therapy and diclofenac for the treatment of AK, both individually and as part of combination therapy regimens. Key words. actinic keratosis guidelines.

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