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Buccal administration is a topical route of administration by which drugs held or applied in the buccal (/ ˈ b ʌ k əl /) area (in the cheek) diffuse through the oral mucosa (tissues which line the mouth) and enter directly into the bloodstream.
Buccal administration involves placement of the drug between the gums and the cheek. These medications can come in the form of tablets, films, or sprays. Many drugs are designed for sublingual administration, including cardiovascular drugs, steroids, barbiturates, opioid analgesics with poor gastrointestinal bioavailability, enzymes and ...
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What is Buccal administration?
Why is Buccal administration better than oral administration?
What is the difference between sublingual and buccal medication administration?
What is a buccal route?
Buccal Administration Route. The buccal route is a medication route that nurses can use to administer certain medications. Although this is not used as commonly as other medication routes, there are a few things to consider when giving a medication via the buccal route.
Buccal administration is intended for delivering drugs within/through the buccal mucosa in order to achieve a local or systemic effect. This route is particularly attractive since substances absorbed through the buccal mucosa bypass gastrointestinal enzymatic degradation and the hepatic first-pass effect.
Multi-purpose tablets—Soluble tablets for either oral or sublingual (or buccal) administration, often also suitable for preparation of injections, Hydrostat ( hydromorphone) and a number of brands of morphine tablets and cubes. Sublingual spray—spray for the tongue; certain human and veterinary drugs are dispensed as such.
Buccal administration involves placing a drug between the gums and cheek, where it dissolves and is absorbed into the blood vessels. This method bypasses the first-pass metabolism , allowing for a higher bioavailability of the drug and faster onset of action.
To develop active drugs with optimized formulations for buccal administration, prediction of the absorption profile of the drug across buccal mucosa, as well as its transport mechanism, is of great importance in drug development.
