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  1. Jun 28, 2023 · Given the many drugs used to manage the infection, people with HIV are at higher risk of developing drug hypersensitivity. Mild cases of drug hypersensitivity typically involve a maculopapular rash with a delayed allergic reaction, usually appearing between one to six weeks.

    • Molly Burford
  2. Mar 25, 2024 · An HIV-related rash usually looks like a reddened or purplish patch of skin — depending on your skin tone — that is flat rather than raised. The area may also contain many small bumps. However, many different conditions can cause similar rashes. Moreover, HIV-related rashes may also take other forms, depending on the underlying cause.

  3. During the acute HIV infection syndrome (in the first few weeks after initial exposure), patients can develop a symmetrical maculopapular erythematous exanthem that involves the face, palms, soles, trunk, and limbs, in conjunction with systemic viral symptoms.

  4. Small, red, intensely itchy, firm papules. Induce scratching. Evolve into hyperpigmented macules and nodules. Most common on exposed skin, particularly the extremities. Sparing of mucous membranes, palms and soles, and web spaces. PPE of HIV has not been observed in the immune reconstitution inflammatory syndrome (IRIS).

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