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  1. A drug rash or other reaction may occur for several reasons, such as: an allergic reaction; a buildup of the drug that causes toxicity to the skin; a drug makes the skin more sensitive...

    • Antibiotics like Bactrim. Antibiotics are notorious for a risk of causing skin rashes and allergic reactions. Sulfa and penicillin antibiotics are common culprits.
    • Hydralazine. Hydralazine is a blood pressure medication that can cause drug-induced lupus erythematosus (DILE). This is the same as the autoimmune condition systemic lupus erythematosus.
    • NSAIDs like aspirin. Aspirin is a pain and fever reducer. It’s a type of nonsteroidal anti-inflammatory drug (NSAID), alongside medications like ibuprofen (Advil, Motrin) and naproxen (Aleve).
    • Furosemide. Furosemide (Lasix) is a diuretic, commonly known as a “water pill”. Like Bactrim, it’s part of the sulfonamide family. So if you have an allergy to sulfa antibiotics, it’s possible you could react to furosemide too.
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  3. Apr 7, 2022 · Rashes are a common side effect of many medications, and while they can be annoying, they typically run their course over a week or two. But not all drug rashes are mild — and some can even be deadly.

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  4. dermnetnz.org › topics › drug-eruptionsDrug eruptions | DermNet

    The main thing is to identify and stop the responsible drug as soon as possible. The use of systemic steroids for drug eruptions, for example, prednisone, is controversial. They are unnecessary if the rash is mild. Get advice from a specialist immunologist or dermatologist if the rash is severe.

  5. Jun 16, 2017 · Immune-Related Drug Reactions. Exanthematous Drug Eruptions: Exanthematous drug eruptions, also known as morbilliform or maculopapular drug eruptions, are the most common of all drug-induced reactions. 6 This type of reaction, which is delayed, manifests 1 to 2 weeks after drug initiation but can occur up to 1 week after the drug is stopped; it ...

  6. Fixed drug eruption (FDE) is a cutaneous adverse drug reaction characterized by recurrent well-demarcated lesions occurring in the same sites every time the culprit drug is taken. These can be caused only by means of an exogenous substance (drug) and not spontaneously or after infection.

  7. Antibiotics that contain sulfa, barbiturates, isoniazid, penicillins, and phenytoin. Fixed drug eruption. A dark red or purple rash that reacts at the same site. Antibiotics and phenolphthalein (found in certain laxatives) Hives. Raised red bumps. Aspirin, certain medicine dyes, penicillins, and many other medicines.

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