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Oxidative stress
- ASD is caused by oxidative stress in several ways, including protein post-translational changes (e.g., carbonylation), abnormal metabolism (e.g., lipid peroxidation), and toxic buildup [e.g., reactive oxygen species (ROS)].
www.ncbi.nlm.nih.gov › pmc › articlesOxidative Stress in Autism Spectrum Disorder—Current Progress ...
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Dec 1, 2021 · A large body of evidence, including decades of research on lead and child IQ, indicate a link between toxic environmental exposures and poorer neurodevelopmental outcomes. 5 In animal models and human studies, several toxic chemicals have been implicated in ASD and ASD-related traits and biological markers. 2 Specifically, scientists have found ...
Feb 11, 2014 · Toxicants implicated in ASD included pesticides, phthalates, polychlorinated biphenyls (PCBs), solvents, toxic waste sites, air pollutants and heavy metals, with the strongest evidence found for air pollutants and pesticides.
- D A Rossignol, S J Genuis, R E Frye
- 10.1038/tp.2014.4
- 2014
- Transl Psychiatry. 2014 Feb; 4(2): e360.
Environmental chemical exposures are increasingly understood to be important in causing autism, with current theories positing that autism is caused by the interplay of multiple genetic and environmental contributions that differ from individual to individual. 4,5 While initial studies suggested a strong genetic heritability of autism, recent ...
- Amy E. Kalkbrenner, Rebecca Jean Schmidt, Annie C. Penlesky
- 10.1016/j.cppeds.2014.06.001
- 2014
- 2014/11
Mar 13, 2020 · Environmental, immunological, genetic, and epigenetic factors are implicated in the pathophysiology of autism and provoke the occurrence of neuroanatomical and neurochemical events relatively early in the development of the central nervous system.
- Rosa Marotta, Maria C. Risoleo, Giovanni Messina, Lucia Parisi, Marco Carotenuto, Luigi Vetri, Miche...
- 2020
Apr 25, 2012 · The top ten chemicals are: 1. Lead. 2. Methylmercury. 3. PCBs. 4. Organophosphate pesticides. 5. Organochlorine pesticides. 6. Endocrine disruptors. 7. Automotive exhaust. 8. Polycyclic...
May 17, 2021 · Molecular Psychiatry - Environmental exposures associated with elevated risk for autism spectrum disorder may augment the burden of deleterious de novo mutations among probands
- Kealan Pugsley, Stephen W Scherer, Mark A Bellgrove, Ziarih Hawi
- 2021
Apr 3, 2019 · This scoping review aimed to identify and categorize primary research and reviews on the association between prenatal and early postnatal exposure to environmental chemicals and the development of autism in epidemiological studies and rodent models of autism.