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As chloroform is a volatile organic compound, it dissipates readily from soil and surface water and undergoes degradation in air to produce phosgene, dichloromethane, formyl chloride, carbon monoxide, carbon dioxide, and hydrogen chloride. Its half-life in air ranges from 55 to 620 days. Biodegradation in water and soil is slow. Chloroform does ...
Breathing low levels of chloroform for a short amount of time can cause you to become dizzy, tired, or give you a headache. At high levels, you may also have trouble breathing and may pass out. Breathing or drinking a large amount of chloroform can cause severe liver and kidney damage, and at very high exposure levels, can cause death.
The average amount of chloroform that you might be exposed to on a typical day by breathing air in various places ranges from 2 to 5 micrograms per day (μg/day) in rural areas, 6 to 200 μg/day in cities, and 80 to 2,200 μg/day in areas near major sources of the chemical.
With exposure at 1 ppm, a human breathing at 10 L/min (an average resting rate) would inhale 70.4 mg of chloroform over a 24-h period (1 ppm = 4.89 mg/m 3), or about 1 mg/kg per day. Gavaged mice exposed at 60 mg/kg per day developed tumors; those exposed at 17 mg/kg per day did not.
Apr 27, 2012 · Workers exposed to chloroform at 71 ppm (4 h/day for 10-24 months) experienced mild symptoms (dryness of mouth and throat) whereas workers exposed at 77-232 ppm over a period of 3-10 years exhibited notable signs of exposure (staggering).
A provisional acute-duration (≤14 days) oral MRL of 0.3 mg/kg/day was derived. A provisional intermediate-duration (15– 364 days) oral MRL of 0.1 mg/kg/day was derived. A provisional chronic-duration (≥365 days) oral MRL of 0.02 mg/kg/day was derived. Health Effects.
Highlights. Exposure to chloroform can occur when breathing contaminated air or when drinking or touching the substance or water containing it. Breathing chloroform can cause dizziness, fatigue, and headaches. Breathing chloroform or ingesting chloroform over long periods of time may damage your liver and kidneys.
