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  1. This is a list of cities in South America. Largest cities [ edit ] This list includes all South American cities with a population within city limits exceeding 500,000 according to official census figures, estimates or projections as of 2015, the most recent year for which official population census results, estimates or short-term projections ...

    • Bonnie Hamre
    • Buenos Aires, Argentina. Big, sprawling Buenos Aires, the capital of Argentina, is cosmopolitan and yet retains a neighborhood feel in the barrios. Sightseeing, nightlife, including the sensual tango, is a must in this sophisticated city.
    • Rio de Janeiro, Brazil. Truly a cidade maravilhosa, Rio is spectacularly located, and to live up to the scenery, cariocas and visitors enjoy a vivid lifestyle nestled between fabulous beaches and rainforested hills.
    • Santiago, Chile. Chile's capital city is cosmopolitan, the financial, cultural, and political center of the country. It's graced with tree-lined streets, parks, distinctive neighborhoods, ample assortment of restaurants and hotels.
    • Sao Paulo, Brazil. The city is South America's largest, Brazil's center of trade and industry. Paulistanos work hard and play hard. Here are some of the things you'll enjoy when you visit São Paulo.
    • La Paz, Bolivia
    • Baños, Ecuador
    • Medellin, Colombia
    • Colonia Del Sacramento, Uruguay
    • Buenos Aires, Argentina
    • Quito, Ecuador
    • Cusco, Peru
    • Rio de Janeiro, Brazil
    • Cartagena, Colombia
    • Valparaiso, Chile

    If you haven’t heard much about Bolivia travel or about La Paz in general, you’re not alone. La Paz, Bolivia, is still a mostly off-the-beaten-path travel destination, but not for lack of things to do, incredible landscapes, and super cheap travel. Highlights of La Paz include the fascinating Witches Market, where you’ll learn so much about indigen...

    If the sprawling metropolis of La Paz isn’t the travel experience you’re looking for, one of the nicest small cities in South America is Baños, Ecuador. This small town wedged between the Andes Mountain and the Amazon Rainforest in the center of Ecuador is the country’s adventure sports capital. However,it has plenty to do if you’re looking for res...

    World, take note: Medellin’s transformation from a dangerous metropolis to a thriving, bustling city, digital nomad destination, and South American travel hub is complete. The change you’ll see in Medellin is remarkable, and this favorite Colombian cityis well worth a visit. Don’t get sucked into the tourist trap-style things to do in Medellin that...

    With just around 26,000 inhabitants, the tiny city of Colonia del Sacramento is a far cry from some of the massive and sprawling cities in South America you’ll find on the rest of this list. However, this charming city on the Rio de la Plata is a UNESCO World Heritage Siteand a colonial gem, making it a highlight of a trip to Uruguay. Just wanderin...

    Buenos Aires is unlike any other of the countless capital cities in South America. A unique mix of European architecture and culture with New York City hustle and bustle, Buenos Aires has a fascinating mix of influences that you won’t find anywhere else in Latin America. There are so many things to do in Buenos Aires that you’ll never get bored: fr...

    After traveling all around South America, I’ve come to the conclusion that Quito, Ecuador is one of the very BEST cities in South America to visit. I might be biased – I did spend two years living here, after all – but this stunning city in Ecuadorhas so much to offer travelers, whether you’re planning on spending just a few hours or a few weeks he...

    At the heart of Peru’s Sacred Valley, Cusco is one of South America’s most enchanting and beloved cities. With its fascinating mix of Incan and colonial historic architecture, easy access to nearby Incan ruins and natural wonders, and proximity to Machu Picchu, this city has plenty to offer. The historic center of Cusco is a gem, filled with histor...

    Rio de Janeiro has everything you might want from a city in South America. With a variety of spectacular beaches, incredible coastal and mountain views, plenty of cultural events and activities,and cool day trips from Rio de Janeiro,you’ll have a hard time narrowing down your itinerary in Rio de Janeiro. Of course, a must-visit destination in Rio d...

    Located on Colombia’s dreamy Caribbean coast, Cartagena is one of the most popular cities to visit in Colombia, and it’s easy to see why. With a perfect combination of old architecture with a fascinating history (and UNESCO World Heritage status!) and modern luxury, there is something for every kind of traveler in Cartagena. There are plenty of thi...

    Get your hiking shoes on because the hilly coastal city of Valparaiso, Chile will have you climbing some huge hills to explore the town. Don’t let this deter you – it also means you’re in for some killer views of the ocean and the colorful, historic houses that cling perilously to the hillsides. This unique, quirky city is a joy to experience and a...

    • Buenos Aires, Argentina. Quite easily the best city in South America for many, Buenos Aires is a little slice of Europe in South America. Home to many world-class museums, theatres and tango shows it’s a city that will keep you entertained for much longer than a weekend.
    • Rio de Janeiro, Brazil. The city of endless beaches, caipirinhas, samba, football and açai, Rio de Janeiro is one of South America’s most beautiful and fascinating cities.
    • Sucre, Bolivia. As one of the most beautiful colonial cities in Bolivia, Sucre tends to be the firm favourite with travellers in Bolivia. As the country’s past capital, Sucre’s Old Town is full of grand colonial buildings, beautiful cathedrals and museums where you can learn about its past.
    • Cusco, Peru. As one of the best cities to visit in South America and one of the most cultural, Cusco is one of my personal favourites. Cusco was the capital of the Incan empire for three centuries until the Spanish Conquest, making it a hot pot of local, mystical Andean culture as well as its colonial history.
  2. Given its size, South America also has many much smaller cities with populations of under a quarter of a million. These include San Bernardo in Chile (249,858), Portoviejo in Ecuador (170,326) and Puno in Peru (116,552). The smallest city in South America is Tumaco in Colombia, with just 86,713 residents.

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  4. Jan 13, 2022 · The Best Cities In South America. Best cities in Colombia. Bogota; Medellin; Cali; Cartagena; Best cities in Ecuador. Cuenca; Guayaquil; Otavalo; Quito; Best cities in Bolivia. La Paz; Potosi; Sucre; Best cities in Peru. Arequipa; Cusco; Lima; Best cities in Chile. Punta Arenas; Santiago; Valparaiso; Best cities in Argentina. Bariloche; Buenos ...

  5. Jan 14, 2019 · The Five Largest Cities in South America By Population. 1. Sao Paolo - 21.7 Million. Sao Paolo is the largest city in Brazil as well as South America with a metropolitan population of around 21.7 million. It is the 12th largest city in the world by population.

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