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Chronic eosinophilic leukemia is a form of cancer in which too many eosinophils are found in the bone marrow, blood, and other tissues. Most cases are associated with fusion genes. [1] Signs and symptoms may include weight loss, fever, malaise, cough, skin and mucosal lesions, diarrhea, and peripheral neuropathy. Cardiac symptoms are also possible.
Sep 1, 2021 · In the 2017 World Health Organization (WHO) classification, chronic eosinophilic leukemia, not otherwise specified (CEL, NOS), is included as one of 7 distinct diagnostic entities under the major category of myeloproliferative neoplasms (MPNs). 1 WHO defining criteria for CEL, NOS include: (a) peripheral blood eosinophilia >1.5×10 9 /L; (b ...
- Jason Gotlib, William Shomali, Andreas Reiter
- 2021
Abstract. Although HES and CEL are indeed rare clinical entities, interest in these disorders has been reborn due to a renaissance in uncovering the biologic basis of previously idiopathic cases.
- Jason Gotlib
- 2008
Chronic eosinophilic leukemia (CEL) is characterized by clonal eosinophilia and is classified as a myeloproliferative neoplasm (MPN). It is a very rare and aggressive disease in which clonal proliferation of eosinophil progenitor cells causes an increase in eosinophils in peripheral blood, bone marrow, and peripheral tissues.
Jan 17, 2019 · Chronic Eosinophilic Leukemia (CEL) is a chronic myeloproliferative neoplasm (CMPN) characterized by a clonal proliferation of eosinophilic precursors that leads to increased eosinophilia in...
Nov 5, 2020 · Median survival for patients who died of CEL was 5 months (range 0-46 months). This raises the possibility of a dichotomous patient population wherein there is one group of patients with a good prognosis, and a second group with aggressive disease and significantly poorer prognosis.
Chronic eosinophilic leukemia (CEL) is a chronic myeloproliferative disease with unknown etiology in which a clonal proliferation of eosinophilic precursor leads to increased eosinophils in blood, bone marrow, or peripheral tissues.
