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In cell biology, a bleb (or snout) is a bulge of the plasma membrane of a cell, characterized by a spherical, "blister-like", bulky morphology.
Jul 15, 2022 · In this review, we first examine the mechanisms that control the inflation of blebs and bias their formation in the direction of the cell’s leading edge and present current views concerning the role blebs play in promoting cell locomotion.
- Jan Schick, Erez Raz
- Front Cell Dev Biol. 2022; 10: 926394.
- 10.3389/fcell.2022.926394
- 2022
Oct 3, 2016 · Blebs are cellular protrusions that have been shown to be instrumental for cell migration in development and disease. Bleb expansion is driven by hydrostatic pressure generated in the cytoplasm by the contractile actomyosin cortex.
- Ewa K Paluch, Erez Raz
- 10.1016/j.ceb.2013.05.005
- 2013
- 2013/10
Nov 30, 2023 · Blebs are blister-like protrusions that occur at the cell surface (reviewed in [1]). Blebs form, and function, in a series of defined steps. They typically grow to a length of around 2 µm within 30 seconds, before shrinking back for another 120 seconds.
Bleb-based migration, a conserved cell motility mode, has a crucial role in both physiological and pathological processes. Unlike the well-elucidated mechanisms of lamellipodium-based mesenchymal migration, the dynamics of bleb-based migration remain less understood.
Mar 1, 2023 · A study demonstrates that sustained membrane blebs in cancer cells recruit curvature-sensing septins that form plasma membrane-proximal signalling hubs that promote cancer cell survival.
Mar 1, 2008 · Blebs are spherical cellular protrusions that occur in many physiological situations. Two distinct phases make up the life of a bleb, each of which have their own biology and physics: expansion, which lasts ∼30 s, and retraction, which lasts ∼2 min.
