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    Col·o·ny-stim·u·lat·ing fac·tor
    /ˈkälənē ˈstimyəˌlādiNG ˈfaktər/

    noun

    • 1. a substance secreted by bone marrow which promotes the growth and differentiation of stem cells into colonies of specific blood cells.

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  3. Colony-stimulating factors (CSFs) are secreted glycoproteins that bind to receptor proteins on the surfaces of committed progenitors in the bone marrow, thereby activating intracellular signaling pathways that can cause the cells to proliferate and differentiate into a specific kind of blood cell (usually white blood cells.

  4. What are Colony stimulating factors? Colony stimulating factors are glycoproteins that promote production of white blood cells (mainly granulocytes such as neutrophils), in response to infection. Administration of exogenous colony stimulating factors stimulates the stem cells in the bone marrow to produce more of the particular white blood cells.

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  5. Go to: Abstract. The colony-stimulating factors (CSFs) are the master regulators of granulocyte and macrophage populations. There are four different aspects of the connection between the CSFs and cancer: (a) the CSFs can accelerate the regeneration of protective white cells damaged by chemotherapy; (b) the CSFs can mobilize stem cells to the ...

    • Donald Metcalf
    • 10.1158/2326-6066.CIR-13-0151
    • 2013
    • 2013/12
  6. The meaning of COLONY-STIMULATING FACTOR is any of several glycoproteins that promote the differentiation of stem cells especially into blood granulocytes and macrophages and that stimulate their proliferation into colonies in culture.

  7. Jun 28, 2019 · Colony-stimulating factors (CSF) are intriguing molecules, which are glycoproteins that control the production and even some functions of granulocytes and macrophages, the immune...

  8. Colony-stimulating factors are hematopoietic growth factors that induce clonal growth of hematopoietic progenitors in vitro and in vivo. They are produced by macrophages, stromal cells, endothelial cells, and T lymphocytes in the marrow microenvironment.

  9. The colony stimulating factors (CSFs) were named due to their ability to stimulate the formation of colonies of mature cells from single bone marrow progenitor cells in semi solid cultures.

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