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Zinc ions are black spheres, coordinated by cysteines residues (blue). In molecular biology, a RING (short for R eally I nteresting N ew G ene) finger domain is a protein structural domain of zinc finger type which contains a C 3 HC 4 amino acid motif which binds two zinc cations (seven cysteines and one histidine arranged non-consecutively ...
Apr 8, 2009 · In contrast to thumb domains, fingers were defined based on sequential position with respect to the palm domain. A component of the finger domain (fig 3, yellow) was always inserted into the palm domain at the same position. However, the finger domain's secondary structure composition, topology, and interactions with neighboring domains varied.
- Indraneel Majumdar, Lisa N. Kinch, Nick V. Grishin
- 2009
Jul 24, 2021 · These contain RNase domain rich in Serine residues at the carboxyl terminus, an ubiquitin associated domain at the amino terminus besides containing the CCCH zinc finger domain . These are known to mediate the decay of mRNA by the binding of RNase domain to the target mRNA where it depicts an intrinsic ribonuclease action.
- Gurseen Rakhra, Gurmeen Rakhra
- 10.1007/s11033-021-06556-x
- 2021
- Mol Biol Rep. 2021; 48(7): 5735-5743.
Mar 14, 2002 · One of the most abundant domains detected in the Arabidopsis proteome is the RING-finger domain, which was found 365 times in the initial characterization of the genome [ 1 ]. In fact, 1.42% of Arabidopsis proteins contain a RING-domain signature. Thus, it is overrepresented in Arabidopsis as compared to other complete eukaryotic genomes ...
- Peter Kosarev, Klaus F X Mayer, Christian S Hardtke
- 10.1186/gb-2002-3-4-research0016
- 2002
- 2002
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What is a ring-finger domain?
What is a zinc finger domain?
What is a RING domain?
Mar 14, 2002 · Background In computational analysis, the RING-finger domain is one of the most frequently detected domains in the Arabidopsis proteome. In fact, it is more abundant in Arabidopsis than in other eukaryotic genomes. However, computational analysis might classify ambiguous domains of the closely related PHD and LIM motifs as RING domains by mistake. Thus, we set out to define an ordered set of ...
- Peter Kosarev, Klaus F X Mayer, Christian S Hardtke
- 2002
Mar 23, 2020 · Zinc finger (ZF) domains, that represent the majority of the DNA-binding motifs in eukaryotes, are involved in several processes ranging from RNA packaging to transcriptional activation, regulation of apoptosis, protein folding and assembly, and lipid binding. While their amino acid composition varies from one domain to the other, a shared ...
Feb 1, 2001 · For the purposes of this review, we define a zinc finger to be any small, functional, independently folded domain that requires coordination of one or more zinc ions to stabilize its structure. In this article, we review recent advances in the structural biology of zinc finger proteins.
