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  1. Synonyms for OPERATE: use, handle, work, run, manipulate, drive, control, wield; Antonyms of OPERATE: backfire, fizzle, ignore, neglect, misuse, misapply

  2. 4. [no object] medical : to perform surgery. The doctors needed to operate immediately. — often + on. operate on a tumor/patient. OPERATE meaning: 1 : to function or behave in a proper or particular way; 2 : to use and control (something) sometimes used in combination.

  3. b) [ transitive] to control a business or organization Nuns are operating an emergency hospital. 3 system/process/service [ intransitive, transitive] if a system, process, or service operates, or if you operate it, it works The whole tax system is now operating more efficiently.

  4. OPERATING definition: 1. relating to the main business activities of a company: 2. working or being used: 3. relating…. Learn more.

  5. Find 139 different ways to say OPERATE, along with antonyms, related words, and example sentences at Thesaurus.com.

  6. Define operate. operate synonyms, operate pronunciation, operate translation, English dictionary definition of operate. v. op·er·at·ed , op·er·at·ing , op·er·ates v. intr. 1.

  7. operating: [adjective] of, relating to, or used for or in operations.

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