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   What is a thrift phenotype?

   • Frequent reference has been made to ‘thrifty genes’ or ‘thrifty phenotypes’, referring to a variety of metabolic or behavioural traits that in one or the other way imply frugality in the expenditure or storage of energy. However, there is confusion over how the strategy of thrift has been incorporated into human biology.

   Thrift: a guide to thrifty genes, thrifty phenotypes and thrifty norms

   www.nature.com/articles/ijo2009175

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   Are thrifty phenotypes a response to short-term ecological variability?

   • Contrasting with genetic variability emerging over the long-term, thrifty phenotypes represent a response to short-term ecological variability. Physiological plasticity allows the emergence of variability across the life course in response to ecological cues experienced directly or by very recent ancestors.

   Thrift: a guide to thrifty genes, thrifty phenotypes and thrifty norms

   www.nature.com/articles/ijo2009175

   See all results for this question

   Can FGF21 help a metabolically thrifty person lose weight?

   • These results may suggest that FGF21 supplementation could assist metabolically thrifty individuals to increase their metabolism by targeting a metabolic defect and ultimately become more “spendthrift” by increasing their EE, thus preventing future weight gain or favoring diet-induced weight loss.

   Metabolic Determinants of Weight Gain in Humans - PMC

   www.ncbi.nlm.nih.gov/pmc/articles/PMC6481299/

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   What does thrift mean?

   • In general language, thrift implies some degree of prosperity deriving from earlier frugality and careful management of resources.

   Thrift: a guide to thrifty genes, thrifty phenotypes and thrifty norms

   www.nature.com/articles/ijo2009175

   See all results for this question

2. www.ncbi.nlm.nih.gov › pmc › articlesMetabolic Determinants of Weight Gain in Humans - PMC

   www.ncbi.nlm.nih.gov › pmc › articles

   Definition of thrifty and spendthrift metabolic phenotypes. Human metabolic phenotypes can be revealed by measuring the short-term (24 hours) response to fasting and overfeeding (especially, low-protein overfeeding) from conditions of energy balance.

   • Metabolic thrift and the genetic basis of human obesity - PMC

     The many genes that regulate metabolism in humans are...

   • How can we assess "thrifty" and "spendthrift" phenotypes?

     This review summarizes the methods used to identify the...

   • Thrifty metabolism that favors fat storage after caloric ...

     Substances. Energy conservation directed at accelerating...

3. ajcn.nutrition.org › article › S0002-9165(22)01214-XAbout “spendthrift” and “thrifty” phenotypes: resistance and ...

   ajcn.nutrition.org › article › S0002-9165(22)01214-X

   A thrifty phenotype is characterized by a greater decrease in EE with fasting associated with its small increase in response to overfeeding. A thrifty phenotype is thus prone to less weight loss during underfeeding but greater weight gain with overfeeding.

4. www.nature.com › articles › ijo2009175Thrift: a guide to thrifty genes, thrifty phenotypes and ...

   www.nature.com › articles › ijo2009175

   Sep 15, 2009 · Abstract. There is a growing interest in evolutionary models of human adiposity. Frequent reference has been made to ‘thrifty genes’ or ‘thrifty phenotypes’, referring to a variety of metabolic...

   • Author: J C K Wells
   • Email: J.Wells@ich.ucl.ac.uk

   • Publish Year: 2009

5. www.ncbi.nlm.nih.gov › pmc › articlesRecharacterizing the Metabolic State of Energy Balance in ...

   www.ncbi.nlm.nih.gov › pmc › articles

   Mar 2, 2020 · The existence of thrifty versus spendthrift phenotypes, defined by measurement of 24-hour (24h) energy expenditure (24EE) in a whole-room indirect calorimeter during acute fasting and overfeeding, was first proposed in 2001 ( 1 ).