Neonatal sepsis is a common, devastating, and expensive disease with life-long impact plagued by a lack of accurate diagnostic and prognostic testing. Management options and outcomes have not changed for the last 30 years. There is remarkable heterogeneity among studies regarding the case definition of neonatal sepsis.
- James L. Wynn
Oct 10, 2021 · Neonatal sepsis refers to an infection involving bloodstream in newborn infants less than 28 days old. It continues to remain a leading cause of morbidity and mortality among infants, especially in middle and lower-income countries.
Neonatal sepsis is invasive infection, usually bacterial, occurring during the neonatal period. Signs are multiple, nonspecific, and include diminished spontaneous activity, less vigorous sucking, apnea, bradycardia, temperature instability, respiratory distress, vomiting, diarrhea, abdominal distention, jitteriness, seizures, and jaundice.
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Medical Editor: William C. Shiel Jr., MD, FACP, FACR Neonatal sepsis is any infection involving an infant during the first 28 days of life. Neonatal sepsis is also known as "sepsis neonatorum." The infection may involve the infant globally or may be limited to just one organ (such as the lungs with pneumonia ).
One strong contributor to a lack of medical progress is a variable case definition of disease. The inability to agree on a precise definition greatly reduces the likelihood of aligning findings from epidemiologists, clinicians, and researchers, which, in turn, severely hinders progress toward improving outcomes.
- James L. Wynn