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  1. The task force sought to differentiate sepsis from uncomplicated infection and to update definitions of sepsis and septic shock to be consistent with improved understanding of the pathobiology. A definition is the description of an illness concept; thus, a definition of sepsis should describe what sepsis “is.”

  2. Aug 15, 2022 · Critical Appraisal of the Literature. To evaluate clinically relevant articles regarding the diagnosis and early management of sepsis, severe sepsis, and septic shock, a search of the National Library of Medicine PubMed database was performed using the following search terms: sepsis management, septic shock management, and clinical sepsis treatment guidelines, with a date range of 2000 to 2018.

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