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  1. 4 days ago · There is a growing public health need for effective preventive interventions against dengue, a disease caused by four viruses, termed serotypes 1–4. Two dengue vaccines have been licensed, Dengvaxia® (CYD-TDV), developed by Sanofi Pasteur, and Qdenga® (TAK-003), developed by Takeda.

  2. Jan 19, 2022 · A vaccine can help prevent dengue, which is caused by four distinct, but closely related dengue viruses, DENV-1, DENV-2, DENV-3, and DENV-4. Only one dengue vaccine is currently available for use: A tetravalent, live-attenuated dengue vaccine (Dengvaxia®)

  3. May 24, 2022 · At least seven DENV vaccines based on different platforms including live attenuated viruses, inactivated viruses, chimeric live attenuated viruses, DNA, and recombinant proteins have been developed and are currently undergoing different phases of clinical trials (Table. 1) or are under preclinical investigation [ 6 ].

  4. Feb 2, 2024 · Stephanie Soucheray, MA. Dengue. Sesai/ Flickr cc. Results of a phase 3 trial in the New England Journal of Medicine ( NEJM) show 80% protection for the single-dose tetravalent (four-strain) Butantan-Dengue Vaccine (Butantan D-V) among participants with no evidence of previous dengue exposure and 89% protection in those with a history of exposure.

  5. Apr 15, 2023 · Dengue is a major global public health problem requiring a safe and efficacious vaccine as the foundation of a comprehensive countermeasure strategy. Despite decades of attempts, the world has...

  6. The U.S. Food and Drug Administration announced today the approval of Dengvaxia, the first vaccine approved for the prevention of dengue disease caused by all dengue virus serotypes (1, 2, 3...

  7. Mar 29, 2022 · Only one tetravalent dengue vaccine, CYD-TDV (Dengvaxia; Sanofi Pasteur), has already been licensed in endemic countries. Its antigens consist of chimeric viruses, in which genomic sequences encoding envelope proteins of the yellow fever virus were replaced by those of each of the four serotypes of dengue virus.

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