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    • Dengue virus mechanism

      • When a mosquito carrying dengue virus bites a person, the virus enters the skin together with the mosquito's saliva. It binds to and enters white blood cells, and reproduces inside the cells while they move throughout the body.
      en.wikipedia.org/wiki/dengue_fever#:~:text=When%20a%20mosquito%20carrying%20dengue%20virus%20bites%20a,the%20cells%20while%20they%20move%20throughout%20the%20body.
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  2. Dengue virus - Wikipedia

    en.wikipedia.org/wiki/Dengue_virus

    Mechanism of infection Dengue virus ’ (DENV) E envelope protein binds to a cellular receptor. The exact nature of the cellular receptor has not... DENV undergoes endocytosis. Acidification of the endosome leads to a conformational change of E, exposing a fusion... Uncoating occurs in the cytoplasm ...

  3. New antiviral mechanism for dengue therapeutics -- ScienceDaily

    www.sciencedaily.com/releases/2020/07/...

    Jul 13, 2020 · "The inhibitor binds four capsid molecules to form a tetramer. Such capsid tetramers are assembled into dengue virus," said Mark White, Associate Professor at UTMB who co-senior authored the study.

  4. Dengue fever - Wikipedia

    en.wikipedia.org/wiki/Dengue

    Mechanism When a mosquito carrying dengue virus bites a person, the virus enters the skin together with the mosquito's saliva. It binds to and enters white blood cells, and reproduces inside the cells while they move throughout the body.

  5. Mechanism of dengue virus entry into cells revealed

    phys.org/news/2014-02-mechanism-dengue-virus...

    Dengue fever, an infectious tropical disease caused by a mosquito-borne virus, afflicts millions of people each year, causing fever, headache, muscle and joint pains and a characteristic skin rash....

  6. Mechanism of dengue virus entry into cells uncovered by ...

    www.sciencedaily.com/releases/2014/02/...

    Dengue fever, an infectious tropical disease caused by a mosquito-borne virus, afflicts millions of people each year, causing fever, headache, muscle and joint pains and a characteristic skin rash....

    • Dengue Virus infection
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    • NS1 Protein Linked to Fatal Dengue Disease
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    • The mechanism of the enhanced immature dengue virus infection by human prM antibody
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    • Science in Action: Deadly Dengue Virus | California Academy of Sciences
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  7. Feb 05, 2019 · Dengue virus (DENV) particles are released from cells in different maturation states. Fully immature DENV (immDENV) is generally non-infectious, but can become infectious when complexed with anti-precursor membrane (prM) protein antibodies.

  8. Dengue and severe dengue - World Health Organization

    www.who.int/news-room/fact-sheets/detail/dengue...
    • Global Burden of Dengue
    • Transmission
    • Characteristics
    • Treatment
    • Prevention and Control
    • Who Response

    The incidence of dengue has grown dramatically around the world in recent decades. A vast majority of cases are asymptomatic and hence the actual numbers of dengue cases are underreported and many cases are misclassified. One estimate indicates 390 million dengue infections per year (95% credible interval 284–528 million), of which 96 million (67–136 million) manifest clinically (with any severity of disease).1 Another study, of the prevalence of dengue, estimates that 3.9 billion people, in...

    The Aedes aegypti mosquito is the primary vector of dengue. The virus is transmitted to humans through the bites of infected female mosquitoes. After virus incubation for 4–10 days, an infected mosquito is capable of transmitting the virus for the rest of its life. Infected symptomatic or asymptomatic humans are the main carriers and multipliers of the virus, serving as a source of the virus for uninfected mosquitoes. Patients who are already infected with the dengue virus can transmit the in...

    Dengue fever is a severe, flu-like illness that affects infants, young children and adults, but seldom causes death.Dengue should be suspected when a high fever (40°C/104°F) is accompanied by 2 of the following symptoms: severe headache, pain behind the eyes, muscle and joint pains, nausea, vomiting, swollen glands or rash. Symptoms usually last for 2–7 days, after an incubation period of 4–10 days after the bite from an infected mosquito.Severe dengue is a potentially deadly complication due...

    There is no specific treatment for dengue fever.For severe dengue, medical care by physicians and nurses experienced with the effects and progression of the disease can save lives – decreasing mortality rates from more than 20% to less than 1%. Maintenance of the patient's body fluid volume is critical to severe dengue care.

    At present, the main method to control or prevent the transmission of dengue virus is to combat vector mosquitoes through: 1. preventing mosquitoes from accessing egg-laying habitats by environmental management and modification; 2. disposing of solid waste properly and removing artificial man-made habitats; 3. covering, emptying and cleaning of domestic water storage containers on a weekly basis; 4. applying appropriate insecticides to water storage outdoor containers; 5. using of personal ho...

    WHO responds to dengue in the following ways: 1. supports countries in the confirmation of outbreaks through its collaborating network of laboratories; 2. provides technical support and guidance to countries for the effective management of dengue outbreaks; 3. supports countries to improve their reporting systems and capture the true burden of the disease; 4. provides training on clinical management, diagnosis and vector control at the regional level with some of its collaborating centres; 5....

  9. Dengue fever - Symptoms and causes - Mayo Clinic

    www.mayoclinic.org/diseases-conditions/dengue...
    • Overview
    • Symptoms
    • Causes
    • Risk Factors
    • Complications
    • Prevention

    Dengue (DENG-gey) fever is a mosquito-borne disease that occurs in tropical and subtropical areas of the world. Mild dengue fever causes a high fever, rash, and muscle and joint pain. A severe form of dengue fever, also called dengue hemorrhagic fever, can cause severe bleeding, a sudden drop in blood pressure (shock) and death.Millions of cases of dengue infection occur worldwide each year. Dengue fever is most common in Southeast Asia and the western Pacific islands, but the disease has bee...

    Many people, especially children and teens, may experience no signs or symptoms during a mild case of dengue fever. When symptoms do occur, they usually begin four to seven days after you are bitten by an infected mosquito.Dengue fever causes a high fever — 104 F degrees — and at least two of the following symptoms: 1. Headache 2. Muscle, bone and joint pain 3. Nausea 4. Vomiting 5. Pain behind the eyes 6. Swollen glands 7. RashMost people recover within a week or so. In some cases, symptoms...

    Dengue fever is caused by any one of four types of dengue viruses spread by mosquitoes that thrive in and near human lodgings. When a mosquito bites a person infected with a dengue virus, the virus enters the mosquito. When the infected mosquito then bites another person, the virus enters that person's bloodstream.After you've recovered from dengue fever, you have immunity to the type of virus that infected you — but not to the other three dengue fever virus types. The risk of developing seve...

    Factors that put you at greater risk of developing dengue fever or a more severe form of the disease include: 1. Living or traveling in tropical areas. Being in tropical and subtropical areas increases your risk of exposure to the virus that causes dengue fever. Especially high-risk areas are Southeast Asia, the western Pacific islands, Latin America and the Caribbean. 2. Prior infection with a dengue fever virus. Previous infection with a dengue fever virus increases your risk of having seve...

    If severe, dengue fever can damage the lungs, liver or heart. Blood pressure can drop to dangerous levels, causing shock and, in some cases, death.

    One dengue fever vaccine, Dengvaxia, is currently approved for use in those ages 9 to 45 who live in areas with a high incidence of dengue fever. The vaccine is given in three doses over the course of 12 months. Dengvaxia prevents dengue infections slightly more than half the time.The vaccine is approved only for older children because younger vaccinated children appear to be at increased risk of severe dengue fever and hospitalization two years after receiving the vaccine.The World Health Or...

  10. Dengue | CDC

    www.cdc.gov/dengue

    Dengue viruses are spread to people through the bite of an infected Aedes species (Ae. aegypti or Ae. albopictus) mosquito. Dengue is common in more than 100 countries around the world. Forty percent of the world’s population, about 3 billion people, live in areas with a risk of dengue.

  11. Nov 02, 2017 · Dengue virus seen under an electron microscope. Sanofi Pasteur/Institut Pasteur. F or decades there has been a counterintuitive and hotly debated theory about dengue infections: ...