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    • Dengue virus mechanism

      • When a mosquito carrying dengue virus bites a person, the virus enters the skin together with the mosquito's saliva. It binds to and enters white blood cells, and reproduces inside the cells while they move throughout the body.
      en.wikipedia.org/wiki/dengue_fever#:~:text=When a mosquito carrying dengue virus bites a,the cells while they move throughout the body.
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  2. Dengue virus - Wikipedia

    en.wikipedia.org/wiki/Dengue_virus

    Mechanism of infection Dengue virus ’ (DENV) E envelope protein binds to a cellular receptor. The exact nature of the cellular receptor has not... DENV undergoes endocytosis. Acidification of the endosome leads to a conformational change of E, exposing a fusion... Uncoating occurs in the cytoplasm ...

  3. Mechanism of dengue virus entry into cells revealed

    phys.org/news/2014-02-mechanism-dengue-virus...

    Dengue fever, an infectious tropical disease caused by a mosquito-borne virus, afflicts millions of people each year, causing fever, headache, muscle and joint pains and a characteristic skin rash....

  4. Dengue fever - Wikipedia

    en.wikipedia.org/wiki/Dengue

    Mechanism When a mosquito carrying dengue virus bites a person, the virus enters the skin together with the mosquito's saliva. It binds to and enters white blood cells, and reproduces inside the cells while they move throughout the body.

  5. New antiviral mechanism for dengue therapeutics -- ScienceDaily

    www.sciencedaily.com/releases/2020/07/...

    "The inhibitor binds four capsid molecules to form a tetramer. Such capsid tetramers are assembled into dengue virus," said Mark White, Associate Professor at UTMB who co-senior authored the study.

  6. Immunopathological mechanisms in dengue and dengue ...

    journals.lww.com/co-infectiousdiseases/Abstract/...

    The majority of severe infections occur upon secondary encounters with heterologous dengue virus serotypes, suggesting an immune-mediated process. Recent findings . Significant findings in the past year include a greater understanding of dengue virus interactions with target cells such as dendritic cells, hepatocytes and endothelial cells.

    • How Does Wolbachia Block Dengue Virus Transmission?
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  7. Mechanism of dengue virus entry into cells uncovered by ...

    www.sciencedaily.com/releases/2014/02/...

    Dengue fever, an infectious tropical disease caused by a mosquito-borne virus, afflicts millions of people each year, causing fever, headache, muscle and joint pains and a characteristic skin rash....

  8. Mechanism of vertical transmission of the dengue virus in mosquitoes. [Article in English, French] Rosen L. Both experimental and field data suggest that some tropical mosquito-borne flaviviruses, such as dengue and yellow fever, survive dry seasons by vertical (i.e. transgenerational) transmission in their mosquito hosts.

    • L Rosen
    • 24
    • 1987
  9. Dengue and severe dengue - World Health Organization

    www.who.int/news-room/fact-sheets/detail/dengue...
    • Global Burden of Dengue
    • Transmission
    • Characteristics
    • Treatment
    • Prevention and Control
    • Who Response

    The incidence of dengue has grown dramatically around the world in recent decades. A vast majority of cases are asymptomatic and hence the actual numbers of dengue cases are underreported and many cases are misclassified. One estimate indicates 390 million dengue infections per year (95% credible interval 284–528 million), of which 96 million (67–136 million) manifest clinically (with any severity of disease).1 Another study, of the prevalence of dengue, estimates that 3.9 billion people, in...

    The Aedes aegypti mosquito is the primary vector of dengue. The virus is transmitted to humans through the bites of infected female mosquitoes. After virus incubation for 4–10 days, an infected mosquito is capable of transmitting the virus for the rest of its life. Infected symptomatic or asymptomatic humans are the main carriers and multipliers of the virus, serving as a source of the virus for uninfected mosquitoes. Patients who are already infected with the dengue virus can transmit the in...

    Dengue fever is a severe, flu-like illness that affects infants, young children and adults, but seldom causes death.Dengue should be suspected when a high fever (40°C/104°F) is accompanied by 2 of the following symptoms: severe headache, pain behind the eyes, muscle and joint pains, nausea, vomiting, swollen glands or rash. Symptoms usually last for 2–7 days, after an incubation period of 4–10 days after the bite from an infected mosquito.Severe dengue is a potentially deadly complication due...

    There is no specific treatment for dengue fever.For severe dengue, medical care by physicians and nurses experienced with the effects and progression of the disease can save lives – decreasing mortality rates from more than 20% to less than 1%. Maintenance of the patient's body fluid volume is critical to severe dengue care.

    At present, the main method to control or prevent the transmission of dengue virus is to combat vector mosquitoes through: 1. preventing mosquitoes from accessing egg-laying habitats by environmental management and modification; 2. disposing of solid waste properly and removing artificial man-made habitats; 3. covering, emptying and cleaning of domestic water storage containers on a weekly basis; 4. applying appropriate insecticides to water storage outdoor containers; 5. using of personal ho...

    WHO responds to dengue in the following ways: 1. supports countries in the confirmation of outbreaks through its collaborating network of laboratories; 2. provides technical support and guidance to countries for the effective management of dengue outbreaks; 3. supports countries to improve their reporting systems and capture the true burden of the disease; 4. provides training on clinical management, diagnosis and vector control at the regional level with some of its collaborating centres; 5....