Jul 14, 2020 · A multidisciplinary team from The University of Texas Medical Branch at Galveston has uncovered a new mechanism for designing antiviral drugs for dengue virus. The study is currently available in ...
Dengue has emerged as a global health threat, while scientists still know little about how the virus infects cells and causes the disease. To answer these questions, NIAID supports a wide-range of basic research activities aimed at better understanding the biology of the dengue virus, the progression of disease in infected people, and the interactions between the virus and the immune system.
Dengue viruses are spread to people through the bite of an infected Aedes species (Ae. aegypti or Ae. albopictus) mosquito. Dengue is common in more than 100 countries around the world. Forty percent of the world’s population, about 3 billion people, live in areas with a risk of dengue. Dengue is often a leading cause of illness in areas with ...
Jul 14, 2020 · Researchers Discover New Antiviral Mechanism for Development of Dengue Treatment Dengue virus is a mosquito-transmitted viral pathogen, causing 390 million human infections each year
Dec 08, 2017 · Dengue pathogenesis, clinical manifestation, lab diagnosis and treatment Pathogenesis of Dengue: Dengue virus after entering in the body invades the local macrophages and multiply there. Infected local cells then migrate from site of infection to lymph nodes, where monocytes and macrophages are recruited, which become targets of infection.
The antiviral mechanism of action of iminosugars against many enveloped viruses, including dengue virus (DENV), HIV, influenza and hepatitis C virus, is believed to be mediated by inducing misfolding of viral N-linked glycoproteins through inhibition of host endoplasmic reticulum-resident α-glucosid …
Dec 15, 2017 · Some serotypes of dengue virus appear to have mechanisms to slow down this process. Interferon also activates the adaptive immune system, which leads to the generation of antibodies against the virus as well as T cells that directly attack any cell infected with the virus.
Dengue is caused by a virus of the Flaviviridae family and there are four distinct, but closely related, serotypes of the virus that cause dengue (DENV-1, DENV-2, DENV-3 and DENV-4). Recovery from infection is believed to provide lifelong immunity against that serotype.
Jan 11, 2018 · Dengue virus (DENV) utilizes the endoplasmic reticulum (ER) for replication and assembling. Accumulation of unfolded proteins in the ER lumen leads to ER stress and unfolded protein response (UPR).
Feb 16, 2018 · Causes. Dengue fever is caused by any one of four types of dengue viruses spread by mosquitoes that thrive in and near human lodgings. When a mosquito bites a person infected with a dengue virus, the virus enters the mosquito.