Oct 24, 2019 · Dengue is a mosquito-borne viral infection causing a severe flu-like illness and, sometimes causing a potentially lethal complication called severe dengue. The incidence of dengue has increased 30-fold over the last 50 years. Up to 50-100 million infections are now estimated to occur annually in over 100 endemic countries, putting almost half of the world’s population at risk.
Dengue viral infections are one of the most important mosquito borne diseases in the world. They may be asymptomatic or may give rise to undifferentiated fever, dengue fever, dengue haemorrhagic fever (DHF), or dengue shock syndrome. Annually, 100 million cases of dengue fever and half a million cases of DHF occur worldwide. Ninety percent of DHF subjects are children less than 15 years of age ...
Dengue is spread through the bite of an infected mosquito. A pregnant woman already infected with dengue can pass the virus to her fetus during pregnancy or around the time of birth. Dengue can have harmful effects, including death of the fetus, low birth weight, and premature birth.
into the mechanism of dengue virus entry into cells—and aid vaccine and clinical drug development. Specifically, Liu, a postdoctoral scholar in the laboratories of cell biologist Ken Jacobson and
Some serotypes of dengue virus appear to have mechanisms to slow down this process. Interferon also activates the adaptive immune system, which leads to the generation of antibodies against the virus as well as T cells that directly attack any cell infected with the virus.
In Dengue virus, the protein called NS5 binds to host spliceosome complexes and modulates endogenous splicing to change mRNA isoform abundance of antiviral factors. By also interacting with U5 snRNP particles, it reduces the efficiency of pre-mRNA processing, hence resulting in a less restrictive environment for viral replication.
Feb 16, 2018 · Diagnosing dengue fever can be difficult, because its signs and symptoms can be easily confused with those of other diseases — such as malaria, leptospirosis and typhoid fever. Your doctor will likely ask about your medical and travel history.
Feb 01, 2018 · Dengue is of great concern in various parts of the world, especially in tropical and subtropical countries where the mosquito vectors Aedes aegypti and Aedes albopictus are present. The transmission of this virus to humans, by what is known as horizontal transmission, occurs through the bite of infected females of one or other of the two mosquito species. Furthermore, an infected female or ...
Jul 23, 2020 · Epidemiology of dengue fever has substantially changed over the years with respect to prevalent strains, affected geographical locations and severity …
Aug 15, 2018 · This antiviral activity was observed in all four serotypes of DENV. Quinine also modulated innate immune response signaling, giving some insight on its anti-dengue mechanism. 2. Materials and methods 2.1. Cell culture and virus infection