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Apr 9, 2024 · DENV is a positive-sense single stranded RNA virus with a genome of approximately 11 kb encoding for one open reading frame which is directly translated into a polyprotein composed of three...
4 days ago · A complex interaction among virulence factors, host-genes and host immune system is considered to be responsible for dengue virus (DENV) infection and disease progression. Generation of auto-antibodies during DENV infection is a major phenomenon that plays a role in the pathophysiology of dengue hemorrhagic fever and dengue shock syndrome.
1 day ago · A pan-serotype dengue virus inhibitor targeting the NS3–NS4B interaction. Nature 598 , 504–509 (2021). Article ADS CAS PubMed Google Scholar
Apr 9, 2024 · Eventually, the study of host protein changes during dengue infection may provide a beneficial understanding of viral production mechanism and reveal promising targets for the development of...
Apr 10, 2024 · In pathogen recognition, the nucleotide-binding domain (NBD) and leucine rich repeat receptors (NLRs) have noteworthy functions in the activation of the innate immune response. These receptors respond to several viral infections, among them NOD2, a very dynamic NLR, whose role in dengue virus (DENV) infection remains unclear.
2 days ago · Latest press conferences. Official video, audio, and transcripts in English.
Apr 4, 2024 · Despite this importance, the mechanisms by which arboviruses infect the mosquito host and disseminate to tissues required for transmission are not well understood. Here, we provide evidence that mosquito immune cells, known as hemocytes, play an integral role in the dissemination of dengue virus (DENV) and Zika virus (ZIKV) in the mosquito ...
