Dengue virus mechanism
- When a mosquito carrying dengue virus bites a person, the virus enters the skin together with the mosquito's saliva. It binds to and enters white blood cells, and reproduces inside the cells while they move throughout the body.
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1 day ago · Dengue fever is a mosquito-borne tropical disease caused by the dengue virus. Symptoms typically begin three to fourteen days after infection. These may include a high fever, headache, vomiting, muscle and joint pains, and a characteristic skin rash.
5 days ago · Infection with dengue virus induces the production of neutralizing homotypic immunoglobulin G (IgG) antibodies which provide lifelong immunity against the infecting serotype. Infection with dengue virus also produces some degree of cross-protective immunity against the other three serotypes.
Sep 13, 2020 · The 5'UTRs are 95–101 nucleotides long in Dengue virus. There are two conserved structural elements in the Flavivirus 5'UTR, a large stem loop (SLA) and a short stem loop (SLB). SLA folds into a Y-shaped structure with a side stem loop and a small top loop.
Sep 13, 2020 · In mice with dengue, for example, they found that the molecule helped the body produce more antibodies to neutralize the virus. Meanwhile, in those with HIV, they found it also helped produce more antibodies that targeted hard-to-reach areas of the virus. It was also able to enhance a pre-existing flu vaccine's efficacy.
5 days ago · Previously, ADE has been investigated massively in dengue virus [, , ], HIV and Ebola infections. Based on SARS-CoV in vitro studies and mouse models, ADE dysregulates the immune response provoking cytokine surge, lymphopenia and inflammation-based injuries [ 54 ] in lung or other parts of the body in severely infected individuals [ 60 , 61 ].
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6 days ago · Virus severely endangers human life and health, the detection of virus is essential for the prevention and treatment of associated disease. Metal-orga…
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Sep 13, 2020 · Zika virus is related to the dengue, yellow fever, Japanese encephalitis, and West Nile viruses. Since the 1950s, it has been known to occur within a narrow equatorial belt from Africa to Asia. From 2007 to 2016 [update] , the virus spread eastward, across the Pacific Ocean to the Americas, leading to the 2015–2016 Zika virus epidemic .
Sep 13, 2020 · One anti-viral strategy is to interfere with the ability of a virus to infiltrate a target cell. The virus must go through a sequence of steps to do this, beginning with binding to a specific "receptor" molecule on the surface of the host cell and ending with the virus "uncoating" inside the cell and releasing its contents. Viruses that have a lipid envelope must also fuse their envelope with the target cell, or with a vesicle that transports them into the cell before they can uncoat.
Sep 13, 2020 · •Human ubiquitin carboxyl-terminal hydrolase-2 (USP2) inhibitors, such as thiopurine analogs, have been reported to inhibit SARS-CoV papain-like prote…