Mechanism of dengue virus entry into cells uncovered by research Date: February 17, 2014 Source: Biophysical Society Summary: Despite its heavy toll, the prevention and clinical treatment of ...
Jul 14, 2020 · A multidisciplinary team from The University of Texas Medical Branch at Galveston has uncovered a new mechanism for designing antiviral drugs for dengue virus. The study is currently available in ...
The antiviral mechanism of action of iminosugars against many enveloped viruses, including dengue virus (DENV), HIV, influenza and hepatitis C virus, is believed to be mediated by inducing misfolding of viral N-linked glycoproteins through inhibition of host endoplasmic reticulum-resident α-glucosid …
Mechanism of vertical transmission of the dengue virus in mosquitoes.: Both experimental and field data suggest that some tropical mosquito-borne flaviviruses, Although vertical transmission of arboviruses in mosquitoes is considered to be transovarial in nature, observations reported here indicate that this is probably not true for dengue virus.
Dengue Virus Infection and Flow Cytometry Analysis. Infection was performed based on a published protocol 44. Briefly, ~1.5 × 10 5 cells per well were seeded into 24-well plates and allowed to adhere for 4 h. Virus diluted in 250 μl DMEM containing 2% FBS was incubated with the cells at 37°C for 1.5 h.
Feb 16, 2018 · Causes. Dengue fever is caused by any one of four types of dengue viruses spread by mosquitoes that thrive in and near human lodgings. When a mosquito bites a person infected with a dengue virus, the virus enters the mosquito.
Dec 15, 2017 · Some serotypes of dengue virus appear to have mechanisms to slow down this process. Interferon also activates the adaptive immune system, which leads to the generation of antibodies against the virus as well as T cells that directly attack any cell infected with the virus.
Feb 26, 2014 · Mechanism of Dengue Virus Entry into Cells by Global Biodefense Staff February 26, 2014, 2:48 pm Dengue fever, an infectious tropical disease caused by a mosquito-borne virus, afflicts millions of people each year, causing fever, headache, muscle and joint pains and a characteristic skin rash.
Dengue is caused by a virus of the Flaviviridae family and there are four distinct, but closely related, serotypes of the virus that cause dengue (DENV-1, DENV-2, DENV-3 and DENV-4). Recovery from infection is believed to provide lifelong immunity against that serotype.
Dec 08, 2017 · Dengue pathogenesis, clinical manifestation, lab diagnosis and treatment Pathogenesis of Dengue: Dengue virus after entering in the body invades the local macrophages and multiply there. Infected local cells then migrate from site of infection to lymph nodes, where monocytes and macrophages are recruited, which become targets of infection.