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Feb 25, 2015 · DENV structure and the putative receptors for virus entry. (A) Schematic representation of DENV structure composed of a lipid envelope (orange) with the envelope (E) protein homodimers (green, PDB ID: 1OAN) and the membrane (M) proteins (blue, PDB ID: 4B03), surrounding an amorphous nucleocapsid formed by the ssRNA genome associated to capsid (C) protein homodimers (red, PDB ID: 1R6R).
Aug 1, 2017 · NK cells are activated by dengue virus-infected MDDCs. To elucidate the mechanism by which NK cells control DENV infection, we explored in vitro coculture systems. We used dendritic cells as they are the first innate immune cell type that is naturally infected by DENV following a mosquito bite . Both NK cells and monocytes were isolated from ...
Feb 8, 2012 · The dengue virus (DENV) complex is composed of four distinct but serologically related flaviviruses, which together cause the present-day most important emerging viral disease. Although DENV infection induces lifelong immunity against viruses of the same serotype, the antibodies raised appear to con …
Dec 15, 2023 · The incidence rate is increasing yearly, bringing a significant economic burden and medical pressure to the world. Dengue viral infection induces a series of clinical symptoms, among which dengue hemorrhagic fever and dengue shock syndrome are the most serious, and vascular leakage is the main pathological feature.
Feb 24, 2023 · Dengue fever is a dengue virus infection, emerging rapidly and posing public health threat worldwide, primarily in tropical and subtropical countries. Nearly half of the world's population is now at risk of contracting the dengue virus, including new countries with no previous history-like Ethiopia. However, little is known about the epidemiology and impact of the disease in different ...
Sep 16, 2022 · Dengue is a mosquito-borne disease which causes significant public health concerns in tropical and subtropical countries. Dengue virus (DENV) has evolved various strategies to manipulate the innate immune responses of the host such as ‘hiding’ ...
Clinical observations and experimental data bear on possible mechanisms of dengue virus-mediated marrow suppression. Work from the authors' laboratory in which long-term bone marrow cultures were used to investigate interactions between dengue virus and bone marrow cells (stromal elements and haematopoietic progenitors) is also reviewed.
