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- Figure 1 | Dengue virus elicits and blocks cGAS-mediated immunity. DENV infection leads to a loss of mitochondrial membrane integrity, which triggers the release of mitochondrial DNA into the cytosol, inducing the activation of the DNA sensor cGAS and, ultimately, type I IFN-mediated antiviral responses.
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Nov 24, 2020 · The pathogenesis of dengue virus infection is attributed to complex interplay between virus, host genes and host immune response. Host factors such as antibody-dependent enhancement (ADE), memory cross-reactive T cells, anti-DENV NS1 antibodies, autoimmunity as well as genetic factors are major determinants of disease susceptibility.
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The pathogenesis of dengue virus infection is attributed to...
- Dengue Virus
In this chapter we will discuss the evolution of virus and...
- Fig. 1
Apr 12, 2012 · Dengue is a self-limited, systemic viral infection transmitted between humans by mosquitoes. The rapidly expanding global footprint of dengue is a public health challenge with an...
Apr 1, 2022 · Understanding the molecular mechanisms of vector-virus interactions is likely to provide novel targets to be exploited for development of drugs and efficient control strategies. The siRNA mechanism of Aedes mosquitoes can be exploited to confer resistance to DENV in natural uninfected populations.
Dengue virus is a relatively simple positive-sense single-stranded RNA virus that is 50 nm in diameter and has three structural proteins — capsid (C) protein, precursor membrane (prM) protein...
- Gavin Screaton, Juthathip Mongkolsapaya, Juthathip Mongkolsapaya, Sophie Yacoub, Sophie Yacoub, Cath...
- 2015
Dec 15, 2021 · Potential antiviral mechanism and molecular targets of the bioactive compounds inhibiting viral entry and replication of dengue virus. Infection of virus involves various stages: In the initial steps, DENV binds to cell receptors including mannose-binding receptor (MR) and DC-SIGN (dendritic cell-specific ICAM3 grabbing nonintegrin) receptor ...
DENV infection leads to a loss of mitochondrial membrane integrity, which triggers the release of mitochondrial DNA into the cytosol, inducing the activation of the DNA sensor cGAS and, ultimately,...
