Jul 13, 2020 · Jan. 12, 2017 — Flaviviruses -- a family that includes Dengue, Zika and West Nile viruses -- use an unexpected mechanism to hijack the cell's machinery to replicate themselves compared to many ...
This signal then prompts the immune system to attack and subdue the pathogen. Using the dengue virus (DENV) as a model, researchers from the Icahn School of Medicine at Mount Sinai have identified the “viral sensor” that initiates an immune response and have also described how the virus counteracts this mechanism and evades immune detection.
13 December 2017 - Following a consultation of the Global Advisory Committee on Vaccine Safety, the World Health Organization (WHO) finds that the dengue vaccine CYD-TDV, sold under the brand name Dengvaxia, prevents disease in the majority of vaccine recipients but it should not be administered to people who have not previously been infected with dengue virus.
This host alternation imposes a selective pressure on the viral population. Here, we found that dengue virus, the most important viral human pathogen transmitted by insects, evolved a mechanism to differentially regulate the production of viral non-coding RNAs in mosquitos and humans, with a significant impact on viral fitness in each host.
Dec 08, 2017 · The vaccine manufacturer, Sanofi Pasteur, announced in 2017 that people who receive the vaccine and have not been previously infected with a dengue virus may be at risk of developing severe dengue if they get dengue after being vaccinated. Dengue pathogenesis, clinical manifestation, lab diagnosis and treatment
Stéphane Mathis, ... Jean-Michel Vallat, in Neuroepidemiology in Tropical Health, 2018. 18.104.22.168 Arboviruses. Dengue virus-related PNS involvement is due to an autoimmune reaction to the virus, inducing GBS or Miller Fisher syndromes (representing 30% of the neurological complications of Dengue virus infection); these forms are similar to the classical GBS.
Jul 01, 2020 · Dengue virus (DENV) is a medically important flavivirus and the aetiological agent of Dengue, a normally self-resolving febrile illness that, in some individuals, can progress into Severe Dengue (SD), a life-threatening disorder that manifests as organ impairment, bleeding and shock.
Dengue fever is a mosquito-borne tropical disease caused by the dengue virus. Symptoms typically begin three to fourteen days after infection. These may include a high fever, headache, vomiting, muscle and joint pains, and a characteristic skin rash.
Dengue viruses are spread to people through the bite of an infected Aedes species (Ae. aegypti or Ae. albopictus) mosquito. Dengue is common in more than 100 countries around the world. Forty percent of the world’s population, about 3 billion people, live in areas with a risk of dengue. Dengue is often a leading cause of illness in areas with ...
Jan 03, 2017 · Dengue cannot be spread directly from person to person. However, a person infected and suffering from dengue fever can infect other mosquitoes. Humans are known to carry the infection from one country to another or from one area to another during the stage when the virus circulates and reproduces in the blood system.