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Feb 23, 2022 · In recent decades, the incidence of AKI associated with dengue virus infection has increased significantly 10 . Severe dengue affects about 6.0 to 6.7% of patients diagnosed with dengue 17 18 . Among hospitalized patients with severe dengue 3.3% to 4.8% develop AKI, of which 14.1% require dialysis 17 19 24 .
Mar 18, 2022 · Dengue virus prM and E protein sequence alignments of Dengvaxia and TetraVax-DV-TV003 vaccine strains (boldface) and 2017 Burkina Faso dengue virus outbreak genomes for serotypes 1, 2, and 3. Only... The 29 full genomes from the Burkina Faso 2017 outbreak were compared with the Dengvaxia and TetraVax-DV-TV003 vaccine strains for each serotype ...
Nov 15, 2023 · As part of its 2021–2030 sustainable development goals, WHO is targeting zero deaths from dengue virus, an arbovirus that circulates throughout subtropical countries.1 Although health-care access and clinical management are certainly crucial to health outcomes, I argue that, for many countries, the changing epidemiology of dengue virus is resulting in inherent increases in infection ...
Oct 15, 2017 · In this review, the design of peptide drugs, antiviral activities and mechanisms of peptides and peptidomimetics (modified peptides) action against dengue virus are discussed. The development of peptides as inhibitors for viral entry, replication and translation is also described, with a focus on the three main targets, namely, the host cell ...
Mar 30, 2023 · Dengue is a mosquito-borne infection caused by dengue virus (DENV) of the Flaviviridae family. There are four distinct serotypes, DENV-1,-2,-3,-4, which cause outbreaks globally. Infection is often self-resolving, and lifelong immunity against the infecting serotype can be achieved after exposure.
Aug 1, 2017 · NK cells are activated by dengue virus-infected MDDCs. To elucidate the mechanism by which NK cells control DENV infection, we explored in vitro coculture systems. We used dendritic cells as they are the first innate immune cell type that is naturally infected by DENV following a mosquito bite . Both NK cells and monocytes were isolated from ...
The transient period of vascular leakage is usually followed by a rapid recovery and is suggestive of the effects of short-lived biological mediators. Both the innate and the adaptive immune systems are activated in severe dengue and contribute to the cytokine production. We discuss the immunological events elicited during a DENV infection and ...
