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  1. Dengue and Zika virus family uses an unexpected approach to ...

    phys.org/news/2017-01-dengue-zika-virus-family...

    Jan 12, 2017 · A group of researchers in Germany have discovered that flaviviruses—a family that includes Dengue, Zika and West Nile viruses—use an unexpected mechanism to hijack the cell's machinery to ...

  2. Mechanisms of Immune Evasion Induced by a Complex of Dengue ...

    academic.oup.com/jid/article/201/6/923/888927

    Mar 15, 2010 · Dengue is caused by a single-stranded RNA virus, the dengue virus (DENV), which exists as 4 closely related serotypes. During the past decades, DENV have evolved into one of the world's major arthropod-borne viruses, a fact that is revealed by the dramatically increasing number of dengue cases not only in areas where the virus is endemic but also among travelers who have visited tropical ...

  3. Molecular Mechanisms Involved in Antibody‐Dependent ...

    onlinelibrary.wiley.com/doi/full/10.1111/tra.12012

    Sep 21, 2012 · Jin Sun, Min Li, Yinan Wang, Pei Hao, Xia Jin, Elaboration of tetravalent antibody responses against dengue viruses using a subunit vaccine comprised of a single consensus dengue envelope sequence, Vaccine, 10.1016/j.vaccine.2017.09.063, 35, 46, (6308-6320), (2017).

  4. Dengue virus: structure, serotypes and mode of transmission ...

    www.onlinebiologynotes.com/dengue-virus...

    Dec 08, 2017 · Dengue virus: structure, serotypes and mode of transmission Introduction. Dengue is an arthropod borne virus belongs to family Flaviviridae and genus Flavivirus.; Dengue virus is transmitted between people by female mosquitoes Ades aegypti and Ades albopidus, which are found throughout the tropical and sub-tropical regions.

  5. SUMMARY Much remains to be learned about the pathogenesis of the different manifestations of dengue virus (DENV) infections in humans. They may range from subclinical infection to dengue fever, dengue hemorrhagic fever (DHF), and eventually dengue shock syndrome (DSS). As both cell tropism and tissue tropism of DENV are considered major determinants in the pathogenesis of dengue, there is a ...

  6. Zika virus infection enhances future risk of severe dengue ...

    science.sciencemag.org/content/369/6507/1123

    Aug 28, 2020 · Dengue and Zika virus epidemics have been lapping each other around the globe. These are closely related mosquito-borne viruses with about 40% homology within the envelope protein. We know that subsequent dengue infections bring a risk of antibody-dependent disease enhancement. Whereas emphasis has been placed on how prior dengue immunity affects Zika infection, little is known about how prior ...

  7. Natural killer (NK) cells play a protective role against dengue virus (DENV) infection, but the cellular and molecular mechanisms are not fully understood. Using an optimized humanized mouse model, we show that human NK cells, through the secretion of gamma interferon (IFN-γ), are critical in the early defense against DENV infection.

  8. The role of the unfolded protein response in dengue virus ...

    onlinelibrary.wiley.com/doi/full/10.1111/cmi.12734

    Symptomatic dengue virus (DENV) infections range from mild fever to severe haemorrhagic disease and death. Host‐viral interactions play a significant role in deciding the fate of the infection. The unfolded protein response (UPR) is a prosurvival cellular reaction induced in response to DENV‐mediated endoplasmic reticulum stress.

  9. Sep 02, 2010 · Dengue Virus Capsid Interacts with DDX3X–A Potential Mechanism for Suppression of Antiviral Functions in Dengue Infection. Frontiers in Cellular and Infection Microbiology 2018 , 7 DOI: 10.3389/fcimb.2017.00542.

  10. A novel mechanism of antibody-mediated enhancement of ...

    journals.plos.org/plospathogens/article?id=10...

    Sep 15, 2017 · An apparently different mechanism of enhanced infection of FcγR-negative cells from humans (A549), hamsters (BHK-21), mice (NIH3T3), and mosquitoes (C6-36) was demonstrated in experiments with dengue 2 virus (strain PL046) and a mab specific for the prM protein , which forms a complex with E in immature forms of flaviviruses . These findings ...