Here, we found that dengue virus, the most important viral human pathogen transmitted by insects, evolved … PLoS Pathog . 2017 Mar 6;13(3):e1006265. doi: 10.1371/journal.ppat.1006265.
- Claudia V. Filomatori, Juan M. Carballeda, Sergio M. Villordo, Sebastian Aguirre, Horacio M. Pallaré...
Dengue virus disease became a nationally notifiable condition in 2010. Cases are reported to CDC by state, territorial, and local health departments using standard case definitions . This webpage contains final data reported to ArboNET for 2017 .
- Global Burden of Dengue
- Prevention and Control
- Who Response
The incidence of dengue has grown dramatically around the world in recent decades. A vast majority of cases are asymptomatic and hence the actual numbers of dengue cases are underreported and many cases are misclassified. One estimate indicates 390 million dengue infections per year (95% credible interval 284–528 million), of which 96 million (67–136 million) manifest clinically (with any severity of disease).1 Another study, of the prevalence of dengue, estimates that 3.9 billion people, in...
The Aedes aegypti mosquito is the primary vector of dengue. The virus is transmitted to humans through the bites of infected female mosquitoes. After virus incubation for 4–10 days, an infected mosquito is capable of transmitting the virus for the rest of its life. Infected symptomatic or asymptomatic humans are the main carriers and multipliers of the virus, serving as a source of the virus for uninfected mosquitoes. Patients who are already infected with the dengue virus can transmit the in...
Dengue fever is a severe, flu-like illness that affects infants, young children and adults, but seldom causes death.Dengue should be suspected when a high fever (40°C/104°F) is accompanied by 2 of the following symptoms: severe headache, pain behind the eyes, muscle and joint pains, nausea, vomiting, swollen glands or rash. Symptoms usually last for 2–7 days, after an incubation period of 4–10 days after the bite from an infected mosquito.Severe dengue is a potentially deadly complication due...
There is no specific treatment for dengue fever.For severe dengue, medical care by physicians and nurses experienced with the effects and progression of the disease can save lives – decreasing mortality rates from more than 20% to less than 1%. Maintenance of the patient's body fluid volume is critical to severe dengue care.
At present, the main method to control or prevent the transmission of dengue virus is to combat vector mosquitoes through: 1. preventing mosquitoes from accessing egg-laying habitats by environmental management and modification; 2. disposing of solid waste properly and removing artificial man-made habitats; 3. covering, emptying and cleaning of domestic water storage containers on a weekly basis; 4. applying appropriate insecticides to water storage outdoor containers; 5. using of personal ho...
WHO responds to dengue in the following ways: 1. supports countries in the confirmation of outbreaks through its collaborating network of laboratories; 2. provides technical support and guidance to countries for the effective management of dengue outbreaks; 3. supports countries to improve their reporting systems and capture the true burden of the disease; 4. provides training on clinical management, diagnosis and vector control at the regional level with some of its collaborating centres; 5....
Jan 17, 2018 · Dengue virus is a pathogen of global concern and has a huge impact on public health system in low- and middle-income countries. The capsid protein of dengue virus is least conserved among related flavivirus and there is very limited information on the role of cytosolic proteins that interact with dengue virus capsid. We identified DEAD (Asp-Glu-Ala-Asp) Box Helicase 3, an X-Linked (DDX3X ...
- Rinki Kumar, Nirpendra Singh, Malik Z. Abdin, Arvind H. Patel, Guruprasad R. Medigeshi
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Jun 26, 2017 · 1. J Virol. 2017 Jun 26;91(14). pii: e01081-16. doi: 10.1128/JVI.01081-16. Print 2017 Jul 15. Collateral Damage during Dengue Virus Infection: Making Sense of DNA by cGAS.
- Sebastian Aguirre, Ana Fernandez-Sesma
Stéphane Mathis, ... Jean-Michel Vallat, in Neuroepidemiology in Tropical Health, 2018. 188.8.131.52 Arboviruses. Dengue virus-related PNS involvement is due to an autoimmune reaction to the virus, inducing GBS or Miller Fisher syndromes (representing 30% of the neurological complications of Dengue virus infection); these forms are similar to the classical GBS.
Sep 21, 2012 · Jin Sun, Min Li, Yinan Wang, Pei Hao, Xia Jin, Elaboration of tetravalent antibody responses against dengue viruses using a subunit vaccine comprised of a single consensus dengue envelope sequence, Vaccine, 10.1016/j.vaccine.2017.09.063, 35, 46, (6308-6320), (2017).
SUMMARY Much remains to be learned about the pathogenesis of the different manifestations of dengue virus (DENV) infections in humans. They may range from subclinical infection to dengue fever, dengue hemorrhagic fever (DHF), and eventually dengue shock syndrome (DSS). As both cell tropism and tissue tropism of DENV are considered major determinants in the pathogenesis of dengue, there is a ...
Dengue virus (DENV) is the cause of dengue fever.It is a mosquito-borne, single positive-stranded RNA virus of the family Flaviviridae; genus Flavivirus. Five serotypes of the virus have been found, all of which can cause the full spectrum of disease.
Dalrymple NA, Cimica V, Mackow ER (2015) Dengue Virus NS Proteins Inhibit RIG-I/MAVS Signaling by Blocking TBK1/IRF3 Phosphorylation: Dengue Virus Serotype 1 NS4A Is a Unique Interferon-Regulating Virulence Determinant. MBio 6: e00553–00515. 10.1128/mBio.00553-15 [PMC free article] [Google Scholar]