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1 day ago · Author summary This study, conducted from 2012 to 2022, aimed at understanding the dynamics and genetic diversity of dengue virus on Reunion Island, a French overseas department located in the southwestern Indian Ocean, which is regularly affected by dengue epidemics. Several thousand clinical isolates and patient samples were collected from across the island and sequenced, resulting in 877 ...
5 days ago · C-type lectins (CTLs) are a family of carbohydrate-binding proteins and an important component of mosquito saliva. Although CTLs play key roles in immune activation and viral pathogenesis, little is known about their role in regulating dengue virus (DENV) infection and transmission.
4 days ago · Background Dengue Viral Infection (DVI) has become endemic in Pakistan since the first major outbreak in Karachi in 1996. Despite aggressive measures taken by relevant authorities, Pakistan has been dealing with a worsening dengue crisis for the past two decades. DHF is severe form of dengue infection which is linked with significant morbidity and mortality. Early identification of severe ...
4 days ago · IJMS | Free Full-Text | Relationship between the Number of Repeats in the Neck Regions of L-SIGN and Augmented Virus Replication and Immune Responses in Dengue Hemorrhagic Fever. Journals. IJMS. Volume 25. Issue 10. 10.3390/ijms25105497.
3 days ago · A high level of disorder in many viral proteins is a direct consequence of their small genomes, which makes interaction with multiple binding partners a necessity for infection and pathogenicity. A segment of the flaviviral capsid protein (C), also known as the molecular recognition feature (MoRF), undergoes a disorder-to-order transition upon binding to several protein partners. To understand ...
1 day ago · The Proscan web server takes a protein structure as input, which can be provided through the input page (Figure 1A) as a user-input PDB file, or a PDB code to specify structures. Options to control behavior include the capability to only use certain chains, or exclude certain chains, from analysis, and to skip the Rosetta ΔΔG calculations ...
4 days ago · Miller S, Kastner S, Krijnse-Locker J, Bühler S, Bartenschlager R. 2007. The non-structural protein 4A of dengue virus is an integral membrane protein inducing membrane alterations in a 2K-regulated manner. J Biol Chem 282:8873–8882.
