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Mar 22, 2024 · Although vaccines have been used to reduce the global health burden of other flaviviruses, the unique requirement for a single vaccine to protect against four different groups of dengue viruses, and the link between secondary infections and DENV disease pathogenesis, has limited success to date.
Mar 6, 2024 · Overall, the prevalence of DENV infection is varies in Ethiopia [ 18, 19, 20, 21, 22, 23 ]. The burden of dengue is increasing globally. The main contributors to this global spread are increased human movement in arbovirus endemic areas, a lack of vector control, urbanization, and deforestation.
Mar 22, 2024 · The binding free energies of the Impdh2-hit complexes were determined using MM-PBSA analysis. According to the overall conclusions of the study, Daucosterol showed good binding affinity and high structural stability to the binding site residues of the target, therefore it is recommended as a lead compound against dengue.
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Mar 22, 2024 · Between May 2 and June 2, 2017, of 3087 children assessed for eligibility, 3001 (97·2%) were enrolled into the study and baseline sera were collected from 2996 (97·1%). 2778 children completed the entire period of surveillance for acute febrile illness ( figure 1 ).
2 days ago · Hanley et al show that transmission of dengue and Zika virus from Old and New World monkeys is shaped by an immunologically-mediated trade-off between magnitude and duration of replication ...
Mar 11, 2024 · Data. Dengue case data, confirmed by clinical or laboratory tests, were obtained from SINAN between 2000 and 2020 and aggregated over 7-year periods (2000–2006, 2007–2013, and 2014–2020).
Mar 14, 2024 · This mechanism is known as “antibody-dependent enhancement”. With the number of cases rising, the phenomenon needs special attention. To avoid this situation, it is preferable to have ...