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  1. Characterization of the Mode of Action of a Potent Dengue ...

    INTRODUCTION. Dengue virus (DV) belongs to the genus Flavivirus, a large group of emerging pathogens capable of causing severe human diseases.Among these, DV represents the most prevalent mosquito-borne human-pathogenic virus worldwide, comprising 4 serotypes that are transmitted mainly by infected Aedes mosquitoes during a blood meal.

    • Pietro Scaturro, Iuni Margaret Laura Trist, David Paul, Anil Kumar, Eliana G. Acosta, Chelsea M. Byr...
    • 89
    • 2014
  2. New antiviral mechanism for dengue therapeutics -- ScienceDaily

    Jul 13, 2020 · Jan. 12, 2017 — Flaviviruses -- a family that includes Dengue, Zika and West Nile viruses -- use an unexpected mechanism to hijack the cell's machinery to replicate themselves compared to many ...

  3. Abstract. The antiviral mechanism of action of iminosugars against many enveloped viruses, including dengue virus (DENV), HIV, influenza and hepatitis C virus, is believed to be mediated by inducing misfolding of viral N-linked glycoproteins through inhibition of host endoplasmic reticulum-resident α-glucosidase enzymes.

    • Joanna L Miller, Beatrice E Tyrrell, Nicole Zitzmann
    • 5
    • 2018
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    What is the dengue virus?

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  5. This host alternation imposes a selective pressure on the viral population. Here, we found that dengue virus, the most important viral human pathogen transmitted by insects, evolved a mechanism to differentially regulate the production of viral non-coding RNAs in mosquitos and humans, with a significant impact on viral fitness in each host.

    • Claudia V. Filomatori, Juan M. Carballeda, Sergio M. Villordo, Sebastian Aguirre, Horacio M. Pallaré...
    • 53
    • 2017
  6. Neutralization of Acidic Intracellular Vesicles by ...

    Jun 18, 2019 · Dengue fever is one of the most important mosquito-borne viral infections in large parts of tropical and subtropical countries and is a significant public health concern and socioeconomic burden. There is an urgent need to develop antivirals that can effectively reduce dengue virus (DENV) replication and decrease viral load.

    • Eunhye Jung, Sangwoo Nam, Hyeryeon Oh, Sangmi Jun, Hyun-Joo Ro, Baek Kim, Baek Kim, Meehyein Kim, Yu...
    • 4
    • 2019
  7. Dengue virus - Wikipedia

    A recent systematic review and meta-analysis showed that allergic symptoms are one of the core symptoms that are highly associated with dengue severity. Mechanism of infection. Dengue virus’ (DENV) E envelope protein binds to a cellular receptor. The exact nature of the cellular receptor has not been fully elucidated.

  8. A Vaccine For Dengue, Just Approved By The FDA, Has A Dark ...

    May 03, 2019 · In November 2017, Sanofi published an ... But dengue is a tricky virus. Dengue antibodies don't always protect a person. In fact, these antibodies can make an infection worse. The dengue virus ...

  9. Molecular Mechanisms Involved in Antibody‐Dependent ...

    Sep 21, 2012 · Dengue virus enters host cells by interacting with cell surface receptors, e.g. C‐type lectins, followed by clathrin‐mediated endocytosis and trafficking into endosomes. Here, the virion delivers its genome into the host cytosol. The presence of dengue virus can be sensed by receptors on the cell surface, in the endosomes, or in the host cytosol.

  10. SUMMARY Much remains to be learned about the pathogenesis of the different manifestations of dengue virus (DENV) infections in humans. They may range from subclinical infection to dengue fever, dengue hemorrhagic fever (DHF), and eventually dengue shock syndrome (DSS). As both cell tropism and tissue tropism of DENV are considered major determinants in the pathogenesis of dengue, there is a ...

  11. Dengue fever - Wikipedia

    Dengue fever is a mosquito-borne tropical disease caused by the dengue virus. Symptoms typically begin three to fourteen days after infection. These may include a high fever, headache, vomiting, muscle and joint pains, and a characteristic skin rash.