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2 days ago · In the case of dengue virus (DENV), an arbovirus that infects more than 100 million people each year, the situation is even more complex (4, 5). Individuals with high DENV antibody titers are protected from infection and developing severe disease (6–8).
4 days ago · Dengue viruses (DENV) are positive-stranded RNA viruses belonging to the Flaviviridae family. DENV is the causative agent of dengue, the most rapidly spreading viral disease transmitted by mosquitoes. Each year, millions of people contract the virus through bites from infected female mosquitoes of the Aedes species. In the majority of individuals, the infection is asymptomatic, and the immune ...
1 day ago · Dengue is an acute febrile illness viral infection caused by dengue virus (DENV), which is transmitted to humans through the bite of an infected Aedes mosquito 1,2,3.There are four genetically ...
2 days ago · A method for identifying the number of transmission chains of dengue Dengue virus from sequence data and serology found that sequential transmission of DENV typically occurs between households in the same neighborhood, consistent with local, density-dependent transmission and implicate densely populated communities as key sources of viral ...
1 day ago · Participants who had tetravalent dengue purified inactivated vaccine prime and live-attenuated vaccine boost were unprotected against dengue virus-1 infection and further showed increased clinical, immunological, and transcriptomic evidence for inflammation potentially mediated by pre-existing infection-enhancing antibodies. This study highlights the impact of small cohort, human challenge ...
Apr 15, 2024 · A complex interaction among virulence factors, host-genes and host immune system is considered to be responsible for dengue virus (DENV) infection and disease progression. Generation of auto-antibodies during DENV infection is a major phenomenon that plays a role in the pathophysiology of dengue hemorrhagic fever and dengue shock syndrome. Hemostasis, thrombocytopenia, hepatic endothelial ...
Apr 10, 2024 · In pathogen recognition, the nucleotide-binding domain (NBD) and leucine rich repeat receptors (NLRs) have noteworthy functions in the activation of the innate immune response. These receptors respond to several viral infections, among them NOD2, a very dynamic NLR, whose role in dengue virus (DENV) infection remains unclear. This research aimed to determine the role of human NOD2 in THP-1 ...
