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4 days ago · Dengue viruses (DENV) are positive-stranded RNA viruses belonging to the Flaviviridae family. DENV is the causative agent of dengue, the most rapidly spreading viral disease transmitted by mosquitoes. Each year, millions of people contract the virus through bites from infected female mosquitoes of the Aedes species. In the majority of individuals, the infection is asymptomatic, and the immune ...
1 day ago · Dengue virus type 2 (DENV-2) is an arthropod-borne deadly RNA human pathogen transmitted through the mosquito Aedes. The DENV-2 roots viral infection by facilitating entry with its envelope glycoprotein to the receptor protein Dendritic-cell-specific ICAM3-grabbing non-integrin (DC-SIGN) through membrane fusion. Here, an organizational path is reported for inhibiting the transition due to ...
1 day ago · Participants who had tetravalent dengue purified inactivated vaccine prime and live-attenuated vaccine boost were unprotected against dengue virus-1 infection and further showed increased clinical, immunological, and transcriptomic evidence for inflammation potentially mediated by pre-existing infection-enhancing antibodies. This study highlights the impact of small cohort, human challenge ...
2 days ago · Dengue haemorrhagic fever (DHF) is recognized to have high mortality in patients with chronic kidney disease (CKD) and heart failure (HF). They are at high risk of shock during the ascending limb of the critical phase of DHF, fluid overload during convalescence and bleeding throughout the entire illness. Physiological changes and medications used in CKD/HF make the diagnosis and monitoring of ...
4 days ago · Wound contamination and exposure to mold in housing are two potential sources of post-disaster fungal infection, according to Hoenigl. Extensive flooding caused by Hurricane Maria in Puerto Rico 36 and Hurricane Harvey in Texas, 37 both in 2017, was linked to increases in invasive mold infections post-hurricane. 36,37
15 hours ago · The LPS-induced inflammation model is widely used for studying inflammatory processes due to its cost-effectiveness, reproducibility, and faithful representation of key hallmarks. While researchers often validate this model using clinical cytokine markers, a comprehensive understanding of gene regulatory mechanisms requires extending investigation beyond these hallmarks. Our study leveraged ...
1 day ago · So far, seven oncogenic viruses have been identified to promote tumorigenesis. These include the DNA viruses HPV, HBV, EBV, KSHV, MCByV) and the RNA viruses HCV and HTLV-1. For certain viruses, the splicing machinery is highjacked to produced viral proteins and maintain the life cycle of the virus . Therefore, it is not surprising that viruses ...
