Nov 13, 2017 · With a series of natural disasters fresh in our minds, let’s take a closer look at the link between hurricanes, earthquakes, and potential dengue disasters. While Atlantic storms hit the Americas between May and November every year, the 2017 season was particularly devastating.
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Dengue, Dengue virus, dengue hemorrhagic fever, dengue fever, flavivirus, Aedes mosquitoes, DHF, DF, DSS Skip directly to site content Skip directly to page options Skip directly to A-Z link Centers for Disease Control and Prevention.
Dengue virus (DENV) is the cause of dengue fever.It is a mosquito-borne, single positive-stranded RNA virus of the family Flaviviridae; genus Flavivirus. Five serotypes of the virus have been found, all of which can cause the full spectrum of disease.
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Feb 06, 2018 · Sanofi, the vaccine manufacturer, announced on November 29, 2017, that new data showed a loss of efficacy in seronegative patients over time and there was a small but increased risk of severe dengue in these patients, and it would be updating the product labeling to reflect this.
- Karen Frances Eng
Mechanism When a mosquito carrying dengue virus bites a person, the virus enters the skin together with the mosquito's saliva. It binds to and enters white blood cells, and reproduces inside the cells while they move throughout the body.
The discovery and optimization of non-nucleoside dengue viral RNA-dependent-RNA polymerase (RdRp) inhibitors are described. An X-ray-based fragment screen of Novartis’ fragment collection resulted in the identification of a biphenyl acetic acid fragment 3, which bound in the palm subdomain of RdRp.
Jan 04, 2012 · The virus that causes dengue disease is divided into four closely related serotypes (dengue virus 1, 2, 3 and 4), and those serotypes can be further divided into genetic variants, or subtypes.
Jan 01, 2019 · The dengue virus (DENV) is the most prevalent mosquito-borne viral pathogen. Four DENV serotypes have been identified and majority of them are developed into life-threatening dengue hemorrhage fever (DHF) and dengue shock syndrome (DSS). It is a growing global health concern and requires specific antiviral drugs and vaccines.
The discovery and optimization of non-nucleoside dengue viral RNA-dependent-RNA polymerase (RdRp) inhibitors are described. An X-ray-based fragment screen of Novartis’ fragment collection resulted in the identification of a biphenyl acetic acid fragment 3, which bound in the palm subdomain of RdRp. Subsequent optimization of the fragment hit 3, relying on structure-based design, resulted in ...