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Nov 24, 2020 · The present article reviews the current concepts of the various mechanisms involved in the pathogenesis of dengue virus infection and gives a comprehensive overview of the multiple factors responsible for severe clinical manifestations of the disease.
Aug 18, 2016 · Infection with any one of the four dengue virus serotypes can cause disease that ranges from a mild febrile illness through to haemorrhagic fever and shock. This Primer outlines the epidemiology ...
- Maria G. Guzman
Nov 19, 2023 · Dengue is a mosquito-borne disease that is transmitted by the bites of Aedes mosquitoes, including Aedes albopictus and Aedes aegypti.Globally, this mosquito-borne disease is regarded as the most common human arboviral infection. 1 More than 2,000 dengue-associated deaths and over 3.7 million dengue cases have already been reported from 70 countries/territories worldwide as of August 23rd ...
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Mar 18, 2022 · Abstract. Knowledge of contemporary genetic composition of dengue virus (DENV) in Africa is lacking. By using next-generation sequencing of samples from the 2017 DENV outbreak in Burkina Faso, we isolated 29 DENV genomes (5 serotype 1, 16 serotype 2 [DENV-2], and 8 serotype 3).
Dec 15, 2021 · Potential antiviral mechanism and molecular targets of the bioactive compounds inhibiting viral entry and replication of dengue virus. Infection of virus involves various stages: In the initial steps, DENV binds to cell receptors including mannose-binding receptor (MR) and DC-SIGN (dendritic cell-specific ICAM3 grabbing nonintegrin) receptor ...
- 10.1155/2021/4224816
- 2021
- Biomed Res Int. 2021; 2021: 4224816.
Sep 30, 2021 · Abstract. Dengue is a mosquito-borne viral disease (arboviral) caused by the Dengue virus. It is one of the prominent public health problems in tropical and subtropical regions with no effective vaccines. Every year around 400 million people get infected by the Dengue virus, with a mortality rate of about 20% among the patients with severe dengue.
Schematic overview of the lifecycle of dengue virus in a mammalian cell. Upon entry, the virus uncoats to release its RNA genome and replicates in the cytoplasm. Successful replication depends on mulitple interactions between viral RNA and proteins with host factors.
