• Dengue is among the most important mosquito-borne viral disease in the world. The disease is caused by four serologi-cally and genetically distinct viruses termed dengue virus (DENV) -1, -2, -3 and -4. Each DENV has four or more genetic groups (or genotypes). • In the last 50 years, dengue incidence has increased 30-fold, worldwide.
Dengue, one of the most devastating mosquito-borne viral diseases in humans, is a significant life threatening problem in india and other developing countries. the disease, caused by dengue virus ...
Dengue haemorrhagic fever 14 Table 2.2 Non-speciﬁc constitutional symptoms observed in haemorrhagic fever patients with dengue and chikungunya virus infectiona Chikungunya Criteria DHF(%) Fever (%) Injected pharynx 96.8 90.3 Vomiting 57.9 59.4 Constipation 53.5 40.0 Abdominal pain 50.0 31.6 Headache 44.6 68.4 Generalized lymphadenopathy 40.5 30.8
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Infection with any of the 4 dengue virus serotypes results in a diverse range of symptoms, from mild undifferentiated fever to life-threatening hemorrhagic fever and shock. Given that dengue virus infection elicits such a broad range of clinical symptoms, early and accurate laboratory diagnosis is essential for appropriate patient management.
- David A. Muller, Alexandra C. I. Depelsenaire, Paul R. Young
SUMMARY Much remains to be learned about the pathogenesis of the different manifestations of dengue virus (DENV) infections in humans. They may range from subclinical infection to dengue fever, dengue hemorrhagic fever (DHF), and eventually dengue shock syndrome (DSS). As both cell tropism and tissue tropism of DENV are considered major determinants in the pathogenesis of dengue, there is a ...
- Byron E. E. Martina, Penelope Koraka, Albert D. M. E. Osterhaus
Stéphane Mathis, ... Jean-Michel Vallat, in Neuroepidemiology in Tropical Health, 2018. 22.214.171.124 Arboviruses. Dengue virus-related PNS involvement is due to an autoimmune reaction to the virus, inducing GBS or Miller Fisher syndromes (representing 30% of the neurological complications of Dengue virus infection); these forms are similar to the classical GBS.
Aug 01, 2020 · In the future, a more detailed analysis of product-release pathways will help elucidate the role of this conformation in the coupled ATP hydrolysis and translocation mechanisms. 5. Conclusions. In this work we performed MD simulations of the Dengue virus NS3 helicase domain bound to a ssRNA segment in three states of the ATP hydrolysis cycle.
No treatment: No specific antiviral agents exist for dengue. Supportive care is advised: Patients should be advised to stay well hydrated and to avoid aspirin (acetylsalicylic acid), aspirin-containing drugs, and other nonsteroidal anti-inflammatory drugs (such as ibuprofen) because of their anticoagulant properties.
- Global Burden of Dengue
- Prevention and Control
- Who Response
The incidence of dengue has grown dramatically around the world in recent decades. A vast majority of cases are asymptomatic and hence the actual numbers of dengue cases are underreported and many cases are misclassified. One estimate indicates 390 million dengue infections per year (95% credible interval 284–528 million), of which 96 million (67–136 million) manifest clinically (with any severity of disease).1 Another study, of the prevalence of dengue, estimates that 3.9 billion people, in...
The Aedes aegypti mosquito is the primary vector of dengue. The virus is transmitted to humans through the bites of infected female mosquitoes. After virus incubation for 4–10 days, an infected mosquito is capable of transmitting the virus for the rest of its life. Infected symptomatic or asymptomatic humans are the main carriers and multipliers of the virus, serving as a source of the virus for uninfected mosquitoes. Patients who are already infected with the dengue virus can transmit the in...
Dengue fever is a severe, flu-like illness that affects infants, young children and adults, but seldom causes death.Dengue should be suspected when a high fever (40°C/104°F) is accompanied by 2 of the following symptoms: severe headache, pain behind the eyes, muscle and joint pains, nausea, vomiting, swollen glands or rash. Symptoms usually last for 2–7 days, after an incubation period of 4–10 days after the bite from an infected mosquito.Severe dengue is a potentially deadly complication due...
There is no specific treatment for dengue fever.For severe dengue, medical care by physicians and nurses experienced with the effects and progression of the disease can save lives – decreasing mortality rates from more than 20% to less than 1%. Maintenance of the patient's body fluid volume is critical to severe dengue care.
At present, the main method to control or prevent the transmission of dengue virus is to combat vector mosquitoes through: 1. preventing mosquitoes from accessing egg-laying habitats by environmental management and modification; 2. disposing of solid waste properly and removing artificial man-made habitats; 3. covering, emptying and cleaning of domestic water storage containers on a weekly basis; 4. applying appropriate insecticides to water storage outdoor containers; 5. using of personal ho...
WHO responds to dengue in the following ways: 1. supports countries in the confirmation of outbreaks through its collaborating network of laboratories; 2. provides technical support and guidance to countries for the effective management of dengue outbreaks; 3. supports countries to improve their reporting systems and capture the true burden of the disease; 4. provides training on clinical management, diagnosis and vector control at the regional level with some of its collaborating centres; 5....
Dengue viruses are spread to people through the bite of an infected Aedes species (Ae. aegypti or Ae. albopictus) mosquito. Dengue is common in more than 100 countries around the world. Forty percent of the world’s population, about 3 billion people, live in areas with a risk of dengue. Dengue is often a leading cause of illness in areas with ...