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2 days ago · The model reproduced an extensive outbreak in 2015–2016 and substantially reduced dengue epidemics worldwide in 2017–2018, which coincided with the occurrence of a warm IOBW event in 2015–2016 and a cold IOBW event in 2017–2018 . Wavelet coherence between the observed and estimated dengue cases reveals that the model effectively ...
4 days ago · Three crystal structures of full-length dengue virus NS1 complexed with a flavivirus–cross-reactive, NS1-specific monoclonal antibody, 2B7, reveal a protective mechanism by which two domains of NS1 are antagonized simultaneously and provide a mechanistic explanation for 2 B7 protection against NS1 -induced pathology. Expand
4 days ago · Dengue fever, which has an estimated annual infection rate of up to 390 million, mainly affects Central and South America and Southeast Asia. 1,2 Apart from possible direct invasion of dengue fever virus to the neurological system, the disease has been reported to be associated with neurological complications probably attributable to autoimmune reactions and metabolic alterations. 3 Several ...
1 day ago · Dengue, chikungunya: Virus: Dengue virus, chikungunya virus: Aedes mosquitos (particularly Ae. aegypti, Ae. albopictus, Ae. polynesiensis, Ae. scutellaris) Non-human primates (southeast Asia and West Africa) Being bitten by an infected female Aedes spp. mosquito: Dracunculiasis (Guinea-worm disease) Helminth: Dracunculus medinensis: Cyclops spp ...
2 days ago · Central tolerance mechanisms reduce the likelihood of destructive immune response against peptides that are similar to self-proteins (14, 17, 107) (Fig. 1B). Additionally, positive selection contributes to a T cell repertoire biased toward peptides sharing a certain level of similarity with our self-proteins ( 43 , 107 , 108 ).
2 days ago · The cellular consequences of activating FLT3 mutations in blood cancers are poorly understood. In this issue, Yan et al demonstrate that FLT3 activation promotes mitobiogenesis and leukemia progression through a posttranslational control mechanism, linking cell metabolism with derepressed mitochondrial transcription and function.
4 days ago · Dengue, a significant mosquito-borne disease, presents a global health challenge with limited treatment options. Recently, there have been estimates of 390 million dengue infections annually worldwide. Thus, Dengue viruses (DENV) continue to result in a severe burden on human health all over the world. Here, we are introducing the Anti-Dengue Peptide Database (ADPDB) as a comprehensive ...
