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2. www.science.org › doi › 10Antigenic distance between primary and secondary dengue ...

   www.science.org › doi › 10

   Apr 24, 2024 · Our findings suggest that dengue disease risk is determined by a highly nuanced picture, where the specific impact of an infecting virus on patterns of disease will depend on both the characteristics of that virus and the immunity derived from previous circulations of antigenically different viruses, with the effect of a particular virus being ...

3. www.nature.com › articles › s41467/024/47774-8Travel surveillance uncovers dengue virus dynamics and ...

   www.nature.com › articles › s41467/024/47774-8

   Apr 25, 2024 · Dengue virus RNA was sequenced using a pan-serotype, highly multiplexed PCR approach called ‘DengueSeq’ (a derivative of PrimalSeq 64). A detailed protocol, including the DENV1-4 primer ...

4. People also ask

   What virus causes dengue?

   • The disease is caused by dengue virus, an enveloped RNA virus which belongs to the family of flaviviridae. Although most infections are asymptomatic, in 20 to 30 percentages all cases infections are accompanied with high fever and other influenza-like signs of illness.

   [Dengue fever--not just a tropical infectious disease]

   pubmed.ncbi.nlm.nih.gov/27120872/

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   How does a high viral load affect dengue pathogenesis?

   • It is strongly believed by many scientists studying dengue pathogenesis that a high viral load and activation of high numbers of nonprotective T cells result in a “storm” of inflammatory cytokines and other mediators, leading to the increased plasma leakage characteristic of DHF/DSS.

   Dengue Virus Pathogenesis: an Integrated View - PMC

   www.ncbi.nlm.nih.gov/pmc/articles/PMC2772360/

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   How does dengue virus replication work?

   • (See 'The dengue virus replication cycle' above.) ● Dissemination – Viremia is detectable in humans 6 to 18 hours before the onset of symptoms and ends as the fever resolves. (See 'Dissemination' above.) ● Immune response – Both innate and adaptive immune responses induced by DENV infection are likely to play a role in the clearance of infection.

   Dengue virus infection: Pathogenesis - UpToDate

   www.uptodate.com/contents/dengue-virus-infection-pathogenesis

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5. journals.plos.org › plospathogens › articleThe inflammasome pathway is activated by dengue virus non ...

   journals.plos.org › plospathogens › article

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   Apr 25, 2024 · Altogether, our study demonstrates that the inflammasome pathway acts as a sensor of DENV NS1 and contributes to protective responses during DENV infection, potentially identifying the inflammasome pathway as a therapeutic target. Figures.

6. www.who.int › news-room › fact-sheetsDengue and severe dengue - World Health Organization (WHO)

   www.who.int › news-room › fact-sheets

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   Apr 23, 2024 · Most people with dengue have mild or no symptoms and will get better in 1–2 weeks. Rarely, dengue can be severe and lead to death. If symptoms occur, they usually begin 4–10 days after infection and last for 2–7 days. Symptoms may include: high fever (40°C/104°F) severe headache. pain behind the eyes.

7. Videos

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     Dengue Fever | Pathophysiology, Symptoms, Diagnosis & Treatment

     Feb 15, 2020

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     Dengue Explained in 5 Minutes

     Oct 29, 2021

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     Life Cycle of the Dengue Fever Virus — HHMI BioInteractive Video

     Jun 11, 2014

     327.9K Views

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8. www.mdpi.com › 1999/4915/16-5 › 727The Dynamic Relationship between Dengue Virus and the Human ...

   www.mdpi.com › 1999/4915/16-5 › 727

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   May 4, 2024 · Dengue virus (DENV) is a continuing global threat that puts half of the world’s population at risk for infection. This mosquito-transmitted virus is endemic in over 100 countries. When a mosquito takes a bloodmeal, virus is deposited into the epidermal and dermal layers of human skin, infecting a variety of permissive cells, including keratinocytes, Langerhans cells, macrophages, dermal ...

9. www.cdc.gov › dengue › transmissionHow Dengue Spreads | Dengue | CDC

   www.cdc.gov › dengue › transmission

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   May 13, 2024 · Key points. Dengue viruses are usually spread to people through the bites of infected Aedes species mosquitoes. A person infected with dengue during pregnancy can pass the virus to their fetus. Rarely, dengue can be spread through other routes.

10. www.cdc.gov › dengue › hcpClinical Features of Dengue | Dengue | CDC

    www.cdc.gov › dengue › hcp

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    May 14, 2024 · Key points. About 1 in 4 dengue virus infections are symptomatic. Approximately 1 in 20 patients with dengue progress to develop severe, life-threatening disease called severe dengue. Because there are four dengue viruses, people can be infected with DENV multiple times in their life.