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ZIKV-116 primarily inhibits infection at a post-attachment step. To investigate how ZIKV-116 inhibited virus infection, we per-formed pre- and post-attachment neutralization assays with a French Polynesian ZIKV strain (H/PF/2013). As anticipated, prebinding with ZIKV-116 efficiently limited ZIKV infection (Fig. 1 A).
Mar 15, 2010 · It is found that dengue virus not only uses preexisting enhancing antibodies to promote its entry into Fc receptor-bearing cells but also exploits enhancing antibodies for intracellular immune evasion through 2 mechanisms, which are mediated by the suppressive cytokine interleukin 10 and high levels of IL-10. We have found that dengue virus (DENV) not only uses preexisting enhancing antibodies ...
Feb 23, 2022 · In recent decades, the incidence of AKI associated with dengue virus infection has increased significantly 10 . Severe dengue affects about 6.0 to 6.7% of patients diagnosed with dengue 17 18 . Among hospitalized patients with severe dengue 3.3% to 4.8% develop AKI, of which 14.1% require dialysis 17 19 24 .
Sep 16, 2022 · The adaptive immune system is made up of the humoral immune response (mediated by B cells and neutralizing antibodies) and the cell-mediated immune response (mediated by CD4 + and CD8 + T cells). Both arms of the adaptive immune system play important roles in DENV disease pathogenesis ( Figure 3 ) ( Ye et al., 2013 ).
Jul 22, 2023 · Naïve mice bitten by mosquitoes immediately after they took partial blood meals from dengue infected mice showed symptoms of dengue virus, followed by mortality. Incorporation of mechanical transmission into mathematical models of dengue virus transmission suggest that this supplemental transmission route could result in larger outbreaks which ...
Mar 6, 2024 · Dengue is a mosquito-transmitted virus and is the leading cause of arthropod-borne viral disease worldwide, posing a significant global health concern. This disease is also known by various monikers, such as breakbone or 7-day fever, and is characterized by intense muscle spasms, joint pain, and high fever, reflecting both the severity and the duration of symptoms. Although most dengue fever ...
Feb 23, 2017 · However, the underlying-mechanism remains elusive. Aims of the study: To reveal the host microRNA (miRNA) profile with the anti-viral activity after honeysuckle treatment. Materials and methods: Here we reveal the differentially expressed miRNAs by Solexa ® deep sequencing from the blood of human and mice after the aqueous extract treatment.
