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Nov 24, 2020 · The pathogenesis of dengue virus infection is attributed to complex interplay between virus, host genes and host immune response. Host factors such as antibody-dependent enhancement (ADE), memory cross-reactive T cells, anti-DENV NS1 antibodies, autoimmunity as well as genetic factors are major determinants of disease susceptibility.
- Figure - PMC - National Center for Biotechnology Information
The pathogenesis of dengue virus infection is attributed to...
- Production, Transmission, Pathogenesis, and Control of Dengue ...
About 50 to 100 million people are newly infected annually,...
- Molecular mechanism of pathogenesis of dengue virus: Entry ...
Interaction with specific receptor (s) at the cell surface...
- Figure - PMC - National Center for Biotechnology Information
Dec 15, 2021 · About 50 to 100 million people are newly infected annually, with almost 2.5 billion people living at risk and resulting in 20,000 deaths. Dengue virus infection is especially transmitted through bites of Aedes mosquitos, hugely spread in tropical and subtropical environments, mostly found in urban and semiurban areas. Unfortunately, there is no ...
- 10.1155/2021/4224816
- 2021
- Biomed Res Int. 2021; 2021: 4224816.
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Apr 22, 2024 · Additionally, they also reported a compound, JNJ-A07, that exhibits antiviral activity against 21 clinical isolates of the dengue virus, spanning all known serotypes and genotypes of the dengue virus with a similar mechanism of action, but JNJ-1802 was selected over JNJ-A07 due to better preclinical safety profile . Furthermore, several other ...
Interaction with specific receptor (s) at the cell surface is one of the first events in the pathogenesis of Dengue virus. However, relatively little is known about these receptors. Cellular receptors in human monocytes and mouse neural cells are main target for the viral infection. The envelope protein of the virus (E-protein) plays important ...
- Seema, S. K. Jain
- 2005
May 1, 2024 · Dengue is the most rapidly emerging climate-sensitive infection, and there has been a 10-fold rise in cases over the past 20 years. Severe illness is characterized by vascular leakage, organ dysfunction, and severe bleeding which occur due to the direct effects of the viral non-structural protein NS1 and an aberrant host immune response.
Nov 19, 2023 · Dengue is a mosquito-borne disease that is transmitted by the bites of Aedes mosquitoes, including Aedes albopictus and Aedes aegypti.Globally, this mosquito-borne disease is regarded as the most common human arboviral infection. 1 More than 2,000 dengue-associated deaths and over 3.7 million dengue cases have already been reported from 70 countries/territories worldwide as of August 23rd ...
Oct 6, 2021 · The small molecule JNJ-A07 interferes with the interaction between the NS3 and NS4B proteins of dengue virus and reduces the viral load in mice even when first administered at peak ...
