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Nov 24, 2020 · The pathogenesis of dengue virus infection is attributed to complex interplay between virus, host genes and host immune response. Host factors such as antibody-dependent enhancement (ADE), memory cross-reactive T cells, anti-DENV NS1 antibodies, autoimmunity as well as genetic factors are major determinants of disease susceptibility.
- Figure - PMC - National Center for Biotechnology Information
The pathogenesis of dengue virus infection is attributed to...
- Molecular Mechanisms of Antiviral Agents against Dengue Virus
When the concentration was increased to 20 μM, a greater...
- Antiviral Role of Phenolic Compounds against Dengue Virus: A ...
Thus, in the present review, 20 phenolic compounds were...
- Figure - PMC - National Center for Biotechnology Information
1 day ago · Author summary Dengue, caused by dengue virus (DENV), is the most prevalent mosquito-transmitted disease in humans and a significant public health issue worldwide. DENV nonstructural protein 1 (NS1) has been shown to contribute to dengue pathogenesis through the induction of endothelial barrier dysfunction, resulting in hyperpermeability and vascular leak–a key feature of severe dengue ...
4 days ago · Additionally, they also reported a compound, JNJ-A07, that exhibits antiviral activity against 21 clinical isolates of the dengue virus, spanning all known serotypes and genotypes of the dengue virus with a similar mechanism of action, but JNJ-1802 was selected over JNJ-A07 due to better preclinical safety profile . Furthermore, several other ...
Jan 20, 2024 · Introduction. Dengue (DENV) is a virus that poses a serious threat to global health as the etiological agent of dengue fever. Four distinct serotypes have been reported (DENV-1 to -4) which differ ...
Aug 8, 2016 · Author Summary Dengue virus (DENV) is the world’s most prevalent mosquito-borne viral disease and nearly 40% of the world’s population is at risk of infection. Currently, no specific drugs are available to treat dengue or other flaviviral diseases. DENV NS5 is a large protein of 900 amino acids composed of two domains with key enzymatic activities for viral RNA replication in the host cell ...
