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     Endocytosis

     • The dengue virus attaches to the surface of a host cell and enters the cell by a process called endocytosis. Once deep inside the cell, the virus fuses with the endosomal membrane and is released into the cytoplasm. The virus particle comes apart, releasing the viral genome.
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     Dengue Viruses | Learn Science at Scitable - Nature

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   What is the pathogenesis of dengue virus infection?

   • The pathogenesis of dengue virus infection is attributed to complex interplay between virus, host genes and host immune response. Host factors such as antibody-dependent enhancement (ADE), memory cross-reactive T cells, anti-DENV NS1 antibodies, autoimmunity as well as genetic factors are major determinants of disease susceptibility.

   Current Understanding of the Pathogenesis of Dengue Virus Infection

   pubmed.ncbi.nlm.nih.gov/33231723/

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   What causes severe manifestations of dengue virus disease?

   • The exact mechanisms responsible for severe manifestations of dengue virus disease are not yet fully elucidated and are likely to be multifactorial. DENV infection can have diverse presentations in different hosts, which cannot be explained by a single hypothesis alone.

   Current Understanding of the Pathogenesis of Dengue Virus Infection

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   What is a dengue virus (DENV)?

   • Dengue viruses (DENVs) cause the most common arthropod-borne viral disease in man with 50–100 million infections per year. Because of the lack of a vaccine and antiviral drugs, the sole measure of control is limiting the Aedes mosquito vectors. DENV infection can be asymptomatic or a self-limited, acute febrile disease ranging in severity.

   Dengue viruses – an overview - PMC - National Center for

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3. www.ncbi.nlm.nih.gov › pmc › articlesCurrent Understanding of the Pathogenesis of Dengue Virus...

   www.ncbi.nlm.nih.gov › pmc › articles

   Nov 24, 2020 · Dengue is a mosquito-borne Flavivirus infection, primarily transmitted by Aedes aegypti followed by Aedes albopictus mosquito and other species of genus Aedes [ 1, 4]. There are four serotypes of dengue virus which are antigenically distinct namely DENV-1, DENV-2, DENV-3, and DENV-4 [ 5 ].

   • Fig. 1

     The pathogenesis of dengue virus infection is attributed to...

   • An Overview

     DENV infection induces intracellular membrane alterations in...

4. pubmed.ncbi.nlm.nih.gov › 33231723Current Understanding of the Pathogenesis of Dengue Virus ...

   pubmed.ncbi.nlm.nih.gov › 33231723

   Abstract. The pathogenesis of dengue virus infection is attributed to complex interplay between virus, host genes and host immune response. Host factors such as antibody-dependent enhancement (ADE), memory cross-reactive T cells, anti-DENV NS1 antibodies, autoimmunity as well as genetic factors are major determinants of disease susceptibility.

   • Author: Puneet Bhatt, Sasidharan Pillai Sabeena, Muralidhar Varma, Govindakarnavar Arunkumar, Govindakarnava...

   • Publish Year: 2021

5. www.nejm.org › doi › fullDengue | New England Journal of Medicine

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   Apr 12, 2012 · Dengue is a self-limited, systemic viral infection transmitted between humans by mosquitoes. The rapidly expanding global footprint of dengue is a public health challenge with...

6. www.nature.com › scitable › topicpageDengue Viruses | Learn Science at Scitable - Nature

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   Introduction. Viruses are tiny agents that can infect a variety of living organisms, including bacteria, plants, and animals. Like other viruses, the dengue virus is a...

7. www.ncbi.nlm.nih.gov › pmc › articlesMolecular mechanism of pathogenesis of dengue virus: Entry ...

   www.ncbi.nlm.nih.gov › pmc › articles

   Interaction with specific receptor (s) at the cell surface is one of the first events in the pathogenesis of Dengue virus. However, relatively little is known about these receptors. Cellular receptors in human monocytes and mouse neural cells are main target for the viral infection.

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9. www.who.int › news-room › fact-sheetsDengue and severe dengue - World Health Organization (WHO)

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   Mar 17, 2023 · Dengue is a viral infection caused by the dengue virus (DENV), transmitted to humans through the bite of infected mosquitoes. About half of the world's population is now at risk of dengue with an estimated 100–400 million infections occurring each year.