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1. • • This review aims to summarize the complex interaction between DENV and the host cellular machinery, comprising regulatory mechanisms at various molecular levels such as epigenetic modulation of the host genome, transcription of host genes, translation of viral and host mRNAs, post-transcriptional regulation of the host transcriptome, post-translational regulation of viral proteins, and pathways involved in protein degradation.
     jbiomedsci.biomedcentral.com › articles › 10

     Dengue virus pathogenesis and host molecular machineries

2. People also ask

   How does a dengue virus internalize?

   • D Envelope glycoproteins attach to host receptors and form the dengue-host membrane complex, resulting in virus internalization to process its replication and propagation inside the host cell [ 13] Humans and mosquitoes are the primary hosts and vectors of DENV, respectively.

   Dengue virus pathogenesis and host molecular machineries

   jbiomedsci.biomedcentral.com/articles/10.1186/s12929-024-01030-9

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   What is a dengue virus (DENV)?

   • Dengue viruses (DENV) are positive-stranded RNA viruses belonging to the Flaviviridae family. DENV is the causative agent of dengue, the most rapidly spreading viral disease transmitted by mosquitoes. Each year, millions of people contract the virus through bites from infected female mosquitoes of the Aedes species.

   Dengue virus pathogenesis and host molecular machineries

   jbiomedsci.biomedcentral.com/articles/10.1186/s12929-024-01030-9

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   How does a dengue virus interact with the host cellular machinery?

   • During dengue infection, the virus interacts with the host cellular machinery responsible for 5’ capping. DENV employs multiple strategies to hijack and manipulate this process. For instance, the virus sequesters essential host factors involved in capping, such as the cap-binding complex and associated enzymes.

   Dengue virus pathogenesis and host molecular machineries

   jbiomedsci.biomedcentral.com/articles/10.1186/s12929-024-01030-9

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3. journals.plos.org › plospathogens › articleThe inflammasome pathway is activated by dengue virus non ...

   journals.plos.org › plospathogens › article

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   Apr 25, 2024 · Abstract. Dengue virus (DENV) is a medically important flavivirus causing an estimated 50–100 million dengue cases annually, some of whom progress to severe disease. DENV non-structural protein 1 (NS1) is secreted from infected cells and has been implicated as a major driver of dengue pathogenesis by inducing endothelial barrier dysfunction.

4. www.who.int › news-room › fact-sheetsDengue and severe dengue - World Health Organization (WHO)

   www.who.int › news-room › fact-sheets

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   Oct 2, 2023 · Dengue is found in tropical and sub-tropical climates worldwide, mostly in urban and semi-urban areas. While many dengue infections are asymptomatic or produce only mild illness, the virus can occasionally cause more severe cases, and even death. Prevention and control of dengue depend on vector control.

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6. biologynotesonline.com › dengue-and-dengue-virusDengue and Dengue Virus - Overview - Biology Notes Online

   biologynotesonline.com › dengue-and-dengue-virus

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   Apr 14, 2024 · Dengue is a viral illness that is transmitted to humans through the bite of an infected Aedes mosquito. It is a leading cause of illness and death in tropical and subtropical regions of the world, particularly in Asia and Latin America.

7. pubmed.ncbi.nlm.nih.gov › 38649998Dengue virus pathogenesis and host molecular machineries

   pubmed.ncbi.nlm.nih.gov › 38649998

   Apr 22, 2024 · This review aims to summarize the complex interaction between DENV and the host cellular machinery, comprising regulatory mechanisms at various molecular levels such as epigenetic modulation of the host genome, transcription of host genes, translation of viral and host mRNAs, post-transcriptional regulation of the host transcriptome, post-transl...

8. www.mdpi.com › 1999/4915/16-5 › 727The Dynamic Relationship between Dengue Virus and the Human ...

   www.mdpi.com › 1999/4915/16-5 › 727

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   May 4, 2024 · Dengue virus (DENV) is a continuing global threat that puts half of the world’s population at risk for infection. This mosquito-transmitted virus is endemic in over 100 countries. When a mosquito takes a bloodmeal, virus is deposited into the epidermal and dermal layers of human skin, infecting a variety of permissive cells, including keratinocytes, Langerhans cells, macrophages, dermal ...

9. www.nature.com › articles › s41579/024/01055-9A mosquito symbiont controls flaviviruses | Nature Reviews ...

   www.nature.com › articles › s41579/024/01055-9

   1 day ago · To understand the dengue epidemiological implications of Rosenbergiella sp. YN46, the authors analysed its prevalence in mosquitoes from dengue-endemic and low dengue-incidence areas. The symbiont ...